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Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma
Hebei Medical University, Shijiazhuang, China.
Hebei Medical University, Shijiazhuang, China.
Hebei Medical University, Shijiazhuang, China.
Hebei Medical University, Shijiazhuang, China.
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2013 (English)In: Disease Markers, ISSN 0278-0240, Vol. 35, no 3, 195-202 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC.

Patients and methods: Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous (n = 20) and ESCC (n = 64).  

Results: Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC ( p = 0.001). The expression of FXYD-3 was correlated with TNM stages and depth of tumour invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis ( p = 0.086), and FXYD-3 expression tended to be positively related to the expression of PINCH (p = 0.063). Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis (p = 0.001). However, FXYD-3 expression was not correlated with patient,s gender (p = 0.847), age (p = 0.876), tumour location (p = 0.279), size (p = 0.771) , grade of differentiation (p = 0.279), and survival (p = 0.113).

Conclusion: overexpression of FXYD-3 in the cytoplasm may play an important role in the tumourigenesis and development in the human ESCC, particularly in combination with PINCH expression.

Place, publisher, year, edition, pages
IOS Press, 2013. Vol. 35, no 3, 195-202 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-98156DOI: 10.1155/2013/740201ISI: 000323985500001OAI: diva2:652276

Funding Agencies|Science and Technology Research and Development Program of Hebei Province, China|11276103D-40|

Available from: 2013-09-30 Created: 2013-09-30 Last updated: 2013-10-09Bibliographically approved

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Sun, Xiao-Feng
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