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Ultrasound radiation force transport of drugs in tumors
Norwegian University of Science and Technology, Faculty of Natural Sciences and Technology, Department of Physics.
2013 (English)MasteroppgaveStudent thesis
Abstract [en]

Delivery of chemotherapeutic agents administered intravenously to solid tumors tissue in optimal quantities is one of the challenges in the clinic. However, ultrasound improves the delivery of the chemothera- peutic agents various ways depending on the frequency and the acous- tic intensity applied though thermal and/or mechanical interactions with the biological tissues. The mechanical interaction arises due to the ultrasound parameters through acoustic radiation force or cavita- tion. The purpose of this study was hence to investigate the potential of ultrasound radiation force for the enhancement of drug uptake in prostate tumors in vivo using poly(butylcyanoacrylate)(PBCA) nano particles and doxorubicin(Dox) . In this work, the performance of the transducer (3D probe: LA 8.0/128/4D -1169) used of this experiment was studied. The safety issues for both the transducer and the patient that can occur due to the mechanical and thermal damage which are the main critical limits were discussed. In addition, a high power acoustic waves that are pre- cisely localized and precisely controlled in amplitude was the second limit which was required, hence studied. The optimal drive voltage and duty cycle for probe was therefore found to be 18V and 1.25% respectively at 8MHz transmitted frequency and 1.25 sec long pulse with reputation frequency of (PRF) 10KHz. In addition, form the maximum possible settings of the transducer, the ultrasound radiation force (URF), ultrasound thermal heating of the tissue (UTH), and temperature on the tissue were simulated, and found 9800N/m3, 49 X 10^-6 J/m and 4 X 10^-6 oK respectively. Lastly, based on these findings, in vivo animal experiment on mice, in which a prostate cancer cells model implemented, was performed, and the distribution of the administered doxorubicin (Dox) and poly(butylcyanoacrylate) (PBCA) nanoparticles on the target tissue was tested. Hence, al- though it is a little dificult to give a concrete conclusion on the impact of URF on the distribution and penetration of the Dox and the PBCA nano particle with out analyzing in a quantified way, the con- focal laser scanning microscopy reveled no legible significant difference was observed for the distribution of the two drugs when we compared without and with ultrasound exposures.

Place, publisher, year, edition, pages
Institutt for fysikk , 2013. , 115 p.
URN: urn:nbn:no:ntnu:diva-22561Local ID: ntnudaim:10322OAI: diva2:649806
Available from: 2013-09-19 Created: 2013-09-19 Last updated: 2013-09-19Bibliographically approved

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