Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Plasma glycosylphosphatidylinositol phospholipase D (GPI-PLD) and abdominal aortic aneurysm.
Department of Clinical Chemistry, Sundsvall County Hospital, Sweden.
Department of Surgery, Sundsvall County Hospital, Sweden .
Proteomics Core Facility, University of Gothenburg, Sweden .
Mid Sweden University, Faculty of Science, Technology and Media, Department of applied science and design. Department of Clinical Chemistry, Sundsvall County Hospital, Sweden .
2012 (English)In: International Journal of Clinical and Experimental Medicine, ISSN 1940-5901, E-ISSN 1940-5901, Vol. 5, no 4, 306-9 p.Article in journal (Refereed) Published
Abstract [en]

Recent reviews state that a circulating biomarker predicting aortic rupture risk would be a powerful tool to stratify patients with small screen-detected abdominal aortic aneurysm (AAA). In a current proteomic pilot-study elevated levels of the enzyme Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) was shown in patients with small AAA compared with controls without aneurysm. In the present study we investigated the impact of plasma GPI-PLD as a biomarker in patients with AAA in relation to aneurysm size, and rupture. Plasma GPI-PLD was measured in patients with AAA (nonruptured, n=78 and ruptured, n=55) and controls without aneurysm (n=41) matched by age, sex and smoking habit. The plasma GPI-PLD levels were significantly lower in patients with ruptured compared nonruptured AAA which we interpreted as a result of hemodilution due to hemorrhage in patients with ruptured AAA. The plasma GPI-PLD levels were similar in patients with nonruptured AAA compared to the controls without aneurysm. Furthermore, there was no correlation between plasma GPI-PLD and aneurysm size in the group of patients with nonruptured AAA. In conclusion, the present study fails to show a connection between GPI-PLD and AAA. However, the definite role of GPI-PLD as a predictive marker needs to be further clarified in a follow-up cohort study.

Place, publisher, year, edition, pages
2012. Vol. 5, no 4, 306-9 p.
Keyword [en]
Aortic aneurysm, Biomarker, Glycosylphosphatidylinositol phospholipase D
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:miun:diva-19121ISI: 000318527000004PubMedID: 22993649Scopus ID: 2-s2.0-84866038349OAI: oai:DiVA.org:miun-19121DiVA: diva2:647151
Available from: 2013-09-10 Created: 2013-06-07 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

Lindqvist_Plasma_GPI-PLD(151 kB)76 downloads
File information
File name FULLTEXT01.pdfFile size 151 kBChecksum SHA-512
8c09dc1b8828f27fd01cd44e9e8f93f5a5e4970c320bf43ca5d01e2e1f02a0a457f269a7775ae885f318fb9662e7e4d53cdeccd362d8aa3b39dcd51a7694dc6c
Type fulltextMimetype application/pdf

PubMedScopus

Search in DiVA

By author/editor
Henriksson, Anders E.
By organisation
Department of applied science and design
In the same journal
International Journal of Clinical and Experimental Medicine
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 76 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 48 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf