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Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
2013 (English)In: Frontiers in Neural Circuits, ISSN 1662-5110, E-ISSN 1662-5110, Vol. 7, 120- p.Article in journal (Refereed) Published
Abstract [en]

Synchronization among neurons is thought to arise from the interplay between excitation and inhibition; however, the connectivity rules that contribute to synchronization are still unknown. We studied these issues in hippocampal CA1 microcircuits using paired patch clamp recordings and real time computing. By virtually connecting a model interneuron with two pyramidal cells (PCs), we were able to test the importance of connectivity in synchronizing pyramidal cell activity. Our results show that a circuit with a nonreciprocal connection between pyramidal cells and no feedback from PCs to the virtual interneuron produced the greatest level of synchronization and mutual information between PC spiking activity. Moreover, we investigated the role of intrinsic membrane properties contributing to synchronization where the application of a specific ion channel blocker, ZD7288 dramatically impaired PC synchronization. Additionally, background synaptic activity, in particular arising from NMDA receptors, has a large impact on the synchrony observed in the aforementioned circuit. Our results give new insights to the basic connection paradigms of microcircuits that lead to coordination and the formation of assemblies.

Place, publisher, year, edition, pages
2013. Vol. 7, 120- p.
Keyword [en]
hippocampus, synchronization, dynamic clamp, I-h, AMPA, NMDA
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-206440DOI: 10.3389/fncir.2013.00120ISI: 000322166700001OAI: oai:DiVA.org:uu-206440DiVA: diva2:644941
Available from: 2013-09-02 Created: 2013-08-30 Last updated: 2017-12-06Bibliographically approved

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