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Intraepithelial lymphocyte distribution differs between the bulb and the second part of duodenum
Oskarshamn Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Gastroentorology.
2013 (English)In: BMC Gastroenterology, ISSN 1471-230X, E-ISSN 1471-230X, Vol. 13Article in journal (Refereed) Published
Abstract [en]

Background

Evaluation of intraepithelial duodenal lymphocytosis (IDL) is important in celiac disease (CD). There is no established cut-off value for increased number of IELs in the bulb.

We therefore investigated the relation between IEL counts in the bulb and duodenal specimens in non-celiac subjects.

Methods

The number of CD3+ IELs was determined in specimens from the second part of the duodenum and from the bulb in 34 non-celiac subjects. The numbers of IELs in the villus tip and sides were counted and the quotient tip/side was calculated. HLA DQ2/DQ8 and serum antibodies against transglutaminase were analysed.

Results

The mean number of IELs per 100 enterocytes (95% CI) in specimens was 14.7 (11.8-17.6) in the bulb, and 21.2 (17.0-25.5) in the second part of the duodenum (p<0.01). There was no difference in IEL count or distribution comparing patients carrying or lacking HLA DQ2/DQ8.

Conclusions

IEL count in non-celiac, HLA DQ2/DQ8 positive or negative patients is significantly lower in the bulb than in the second part of the duodenum. These findings implicate that the site of biopsy should be taken into account when considering duodenal lymphocytosis.

Place, publisher, year, edition, pages
BioMed Central , 2013. Vol. 13
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-96711DOI: 10.1186/1471-230X-13-111ISI: 000322132500001OAI: oai:DiVA.org:liu-96711DiVA: diva2:642970
Note

Funding Agencies|Medical Research Council of Southeast Sweden||

Available from: 2013-08-23 Created: 2013-08-23 Last updated: 2017-12-06

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Ignatova, SimoneDahle, CharlotteStröm, Magnus
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Department of Clinical and Experimental MedicineFaculty of Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion MedicineDivision of Inflammation MedicineDepartment of Gastroentorology
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