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Correlation between human natural killer cell migration and cytotoxicity.
KTH, School of Engineering Sciences (SCI), Applied Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics.
2013 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Natural killer cells constitute part of the innate immune system, defending

against cancer tumours and infections. Ongoing research has shown a diering

e-ciency to kill target cells among individual cells in natural killer cell

populations, and new tools allow for in-depth studies of large cell numbers over

an extended period of time.

In this thesis, the killing e-ciency of natural killer cells is correlated with

their migration behaviour. Migratory properties are found to be of either of

two essentially dierent forms, being active or inactive, and killing e-ciency

is demonstrated to not be strongly related to migration behaviour. Further,

natural killer cell populations are shown to exhibit additional heterogeneity as

cells inducing fast death of target cells are shown to dier in migration compared

to cells inducing slow death. Lastly, cells showing exhaustion in cytotoxicity

during the assay are demonstrated to also experience migratory exhaustion.

Place, publisher, year, edition, pages
2013. , 32 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-126487OAI: oai:DiVA.org:kth-126487DiVA: diva2:642343
Supervisors
Available from: 2013-08-21 Created: 2013-08-21 Last updated: 2013-08-21Bibliographically approved

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Ksenia Chechet, Oscar Michelin kandidatex,-rapport(3752 kB)161 downloads
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