Change search
ReferencesLink to record
Permanent link

Direct link
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation with L-tryptophan in Atlantic cod (Gadus morhua)
Show others and affiliations
2013 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 109, no 12, 2166-2174 p.Article in journal (Refereed) Published
Abstract [en]

The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Previous studies in teleosts demonstrate that 7 d of dietary administration with L-tryptophan (Trp), the direct precursor of 5-HT, suppresses the endocrine stress response. The present study investigated how long the suppressive effects of a Trp-enriched feed regimen, at doses corresponding to two, three or four times the Trp levels in commercial feed, last in juvenile Atlantic cod (Gadus morhua) when the fish are reintroduced to a diet with standard amino acid composition. We also wanted to determine whether Trp supplementation induced changes in brain monoaminergic neurochemistry in those forebrain structures innervated by DA- and 5-HTergic neurons, by measuring regional activity of DA and 5-HT in the lateral pallial regions (Dl) of the telencephalon and nucleus lateralis tuberis (NLT) of the hypothalamus. Dietary Trp resulted in a dose-dependent suppression in plasma cortisol among fish exposed to confinement stress on the first day following experimental diet; however, such an effect was not observed at 2 or 6 d after Trp treatment. Feeding the fish with moderate Trp doses also evoked a general increase in DA and 5-HT-ergic activity, suggesting that these neural circuits within the NLT and Dl may be indirectly involved in regulating the acute stress response.

Place, publisher, year, edition, pages
2013. Vol. 109, no 12, 2166-2174 p.
Keyword [en]
Tryptophan, Atlantic cod, Stress response, Nucleus lateralis tuberis, Lateral pallial telencephalon
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-203263DOI: 10.1017/S0007114512004345ISI: 000319608300006OAI: diva2:636276
Available from: 2013-07-09 Created: 2013-07-08 Last updated: 2013-07-29Bibliographically approved

Open Access in DiVA

fulltext(160 kB)78 downloads
File information
File name FULLTEXT01.pdfFile size 160 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Winberg, Svante
By organisation
In the same journal
British Journal of Nutrition
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 78 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 181 hits
ReferencesLink to record
Permanent link

Direct link