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Antidepressiva läkemedels effekt på frakturrisk, hjärt-kärlsystemet och sjukdomsprognos
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
2013 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

Depression är en sjukdom som 15-20% av befolkningen någon gång kommer att drabbas av.Vid behandling av depression används, förutom psykoterapi och elektrokonvulsiv behandling (ECT), antidepressiva läkemedel. De flesta läkemedlen påverkar serotoninåterupptag, men dåserotonin har effekt på andra ställen i kroppen än hjärnan kan det uppstå biverkningar. Vidmånga eller långvariga depressioner kan det bli aktuellt med långtidsbehandling. Riskerna medlångtidsbehandling är inte helt kända, och därför har i denna studie effekterna avlångtidsbehandling med antidepressiva läkemedel undersökts. Detta gjordes med hjälp av enlitteraturstudie utifrån frågeställningarna ”vilka effekter har långtidsbehandling medantidepressiva läkemedel på hjärt-kärlsystemet och frakturrisk?” och ”har långtidsbehandlingmed antidepressiva läkemedel några effekter på depressionssjukdomens prognos?” Studienvisar att antidepressiva läkemedel kan öka risken för frakturer samt påverka hjärt-kärlsystemet,samt att mekanismerna bakom detta fortfarande är oklara.

Abstract [en]

Depression is an illness that 15-20% of all people at some point will suffer from. In thetreatment of depression antidepressants are used but also psychotherapy and electroconvulsivetherapy. Most drugs affect serotonin reuptake, but since serotonin has an effect on other parts of thebody than the brain it may cause side effects. In the case of many or prolonged episodes ofdepression it may be necessary with long-term treatment. The risks of long-term treatment are notfully known, and therefore, in this study the effects of long-term treatment with antidepressants wasexamined. This was done by means of a literature study based on the questions "what is the impactof long-term treatment with antidepressant drugs on the cardiovascular system and fracture risk?"and "has long-term treatment with antidepressants any effects on the prognosis of depression?" Thestudy shows that antidepressants may increase the risk of fractures and affect the cardiovascularsystem, and that the mechanisms behind these are still unclear.

Place, publisher, year, edition, pages
2013. , 25 p.
Keyword [sv]
antidepressiva, läkemedel, långtidseffekter, hjärta, kärl, fraktur, bentäthet, depression
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:lnu:diva-26959OAI: oai:DiVA.org:lnu-26959DiVA: diva2:634357
Subject / course
Biomedical Sciences
Educational program
Health Science Programme with Specialisation in Bio Sciences, 180 credits
Supervisors
Examiners
Available from: 2013-07-26 Created: 2013-06-23 Last updated: 2013-07-26Bibliographically approved

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