Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications
2014 (English)In: Microfluidics and Nanofluidics, ISSN 1613-4982, E-ISSN 1613-4990, Vol. 17, no 4, 773-779 p.Article in journal (Refereed) Published
A new method that allows for mold-free, rapid and easy-to-use proto- typing of micro uidic devices comprising channels, access holes and surface modied patterns, is presented. The innovative method is based on direct photolithographic patterning of an o-stoichiometry thiol-ene (OSTE) polymer formulation, tailor-made for photolithography, which oers unprecedented spatial resolution and allow for ecient, robust and reliable, room temperature surface modication and glue-free, covalent room temperature bonding. This mold-free process does not require cleanroom equipment and therefore allows for rapid, i.e. less than one hour, design-fabricate-test cycles, using a material suited for larger scale production. The excellent photolithographic properties of this new OSTE formulation allow for high-resolution patterning in hundreds of micrometers thick layers, 200 m thick in this work. Moreover, we demonstrate robust (covalent) and spatially controlled modication of the microchannel surfaces with a contact angle of 76 degrees to hydrophobic/hydrophilic areas with contact angles of 102 and 43 degrees, respectively.
Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2014. Vol. 17, no 4, 773-779 p.
lab-on-chip, microfluidics, photolithography, OSTE polymer, surface modi, oste, oste+, OSTEmer, lab-on-chip, off-stoichiometric thiol-ene
Research subject Biotechnology; Materials Science and Engineering
IdentifiersURN: urn:nbn:se:kth:diva-124363DOI: 10.1007/s10404-014-1351-9ISI: 000342454400016ScopusID: 2-s2.0-84920255161OAI: oai:DiVA.org:kth-124363DiVA: diva2:634289
QC 201410272013-06-292013-06-292016-02-16Bibliographically approved