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Trends in the analysis of persistent organic pollutants (POPs) in human blood
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-5752-4196
Örebro University, School of Science and Technology.ORCID iD: 0000-0003-3722-4633
Örebro University, School of Science and Technology.ORCID iD: 0000-0003-4128-8226
Örebro University, School of Science and Technology.ORCID iD: 0000-0002-4959-2807
2013 (English)In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 46, p. 129-138Article in journal (Refereed) Published
Abstract [en]

The general demands on analytical practices in laboratories involved in monitoring concentrations of persistent organic pollutants (POPs) in human blood in the context of the Stockholm Convention are met by the validated analytical procedures applied in most laboratories today. At the same time, as the concentrations of many of the legacy POPs are decreasing in the general populations, more specific, sensitive, and accurate analytical techniques are required. Thus, a challenge for the Stockholm Convention is the analytical capacity, in terms of quality and availability worldwide, to monitor declining concentrations of POPs in human blood. However, other POP issues (e.g., those targeted by epidemiological studies) might require different information and therefore more specialized analytical procedures having greater instrumental sensitivity.

We review current and emerging analytical procedures used for analysis of the chlorinated, brominated, and fluorinated classes of POPs in human blood with a focus on the compounds included in the Stockholm Convention. In general, analytical trends in sample clean-up, separation, detection techniques and quality protocols provide a tool for POP laboratories to measure POPs in human blood. Techniques based on established mass-selective instruments are most commonly employed but declining concentrations in humans in the future might require more selective, more sensitive techniques.

Place, publisher, year, edition, pages
Oxon, UK: Elsevier, 2013. Vol. 46, p. 129-138
Keywords [en]
Gas chromatography (GC), High-resolution mass spectrometry (HRMS), Human blood, Liquid chromatography (LC), Organochlorine (OC) pesticide, Perfluoroalkylated substance (PFAS), Polychlorinated biphenyl (PCB), Polychlorinated dibenzo-p-dioxin (PCDD), Polychlorinated diphenyl ether (PBDE), Stockholm Convention
National Category
Chemical Sciences Analytical Chemistry
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-29858DOI: 10.1016/j.trac.2012.06.009ISI: 000319087800027Scopus ID: 2-s2.0-84876816513OAI: oai:DiVA.org:oru-29858DiVA, id: diva2:634058
Available from: 2013-06-28 Created: 2013-06-28 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Development and application of high-throughput methods for analysis of persistent organic pollutants in human blood
Open this publication in new window or tab >>Development and application of high-throughput methods for analysis of persistent organic pollutants in human blood
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The general public is continuously exposed to a wide range of environmental pollutants. This thesis focuses on a group of anthropogenic chemicals referred to as persistent organic pollutants (POPs) that have been linked to various adverse health effects in humans.

The main objective of this thesis was focused on the development and application of high-throughput methods for analysis of a broad range of chlorinated, brominated, and fluorinated POPs in human blood.

After establishing that the methods were effective, the two methods were applied to human plasma samples to examine the background levels of a broad range of POPs in human plasma samples among elderly men and women from Sweden and to assess the influence of gender. Levels of a wide range of chlorinated, brominated, and fluorinated compounds were determined in plasma samples collected during 2001-2004 from 1, 016 (50.2% women) 70 year-old participants from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). The POPs studied were 16 polychlorinated biphenyls (PCBs), 5 organochlorine pesticides (OCPs), 1 dioxin, 1 brominated flame retardant as well as 14 perfluoroalkyl substances (PFAS) including structural perfluorooctane sulfonic acid (PFOS) isomers. The majority of the studied compounds were detected in the 70-100% of the participants. The structural PFOS isomers were successfully quantified in a sub-sample of 25 men and women. Furthermore, gender differences in the concentrations of the POPs studied showed that the majority of chlorinated and brominated compounds were significantly different when comparing men and women in the study, while the concentrations of the fluorinated compounds were found to be less influenced by gender.

This thesis has, by using the developed high-throughput methods requiring only small amounts of human blood, provided background exposure information of a broad range of POPs for an epidemiological study.

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2013. p. 70
Series
Örebro Studies in Chemistry, ISSN 1651-4270 ; 12
Keywords
Human blood, POPs, Perfluoroalkylated substances, Structural isomers, Sample preparation, Column-switch, Mass spectrometry
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
urn:nbn:se:oru:diva-28456 (URN)978-91-7668-936-3 (ISBN)
Public defence
2013-05-31, Hörsal B, Billbergska huset, Örebro universitet, Fakultetsgatan 1, Örebro, 10:00 (English)
Opponent
Supervisors
Available from: 2013-03-22 Created: 2013-03-22 Last updated: 2017-10-17Bibliographically approved

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