Change search
ReferencesLink to record
Permanent link

Direct link
Dynamics of Hippocampal Neurogenesis in Adult Humans
Show others and affiliations
2013 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 153, no 6, 1219-1227 p.Article in journal (Refereed) Published
Abstract [en]

Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have func- tional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear- bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dy- namics. We found that a large subpopulation of hip- pocampal neurons constituting one-third of the neu- rons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neu- rons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neuro- genesis may contribute to human brain function.

Place, publisher, year, edition, pages
Maryland Heights, MO, USA: Elsevier, 2013. Vol. 153, no 6, 1219-1227 p.
Keyword [en]
Hippocampas, Neurogenesis, regeneration, cell, Humans
National Category
Accelerator Physics and Instrumentation
Research subject
Physics with specialization in Biophysics
URN: urn:nbn:se:uu:diva-202792DOI: 10.1016/j.cell.2013.05.002ISI: 000319979200008OAI: diva2:633569
Swedish Research Council

De två (2) första författarna delar förstaförfattarskapet.

Available from: 2013-06-27 Created: 2013-06-27 Last updated: 2013-07-22Bibliographically approved

Open Access in DiVA

fulltext(13826 kB)371 downloads
File information
File name FULLTEXT02.pdfFile size 13826 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Salehpour, MehranPossnert, Göran
By organisation
Tandem LaboratoryApplied Nuclear Physics
In the same journal
Accelerator Physics and Instrumentation

Search outside of DiVA

GoogleGoogle Scholar
Total: 371 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 523 hits
ReferencesLink to record
Permanent link

Direct link