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Time to secondary progression in patients with multiple sclerosis who were treated with first generation immunomodulating drugs
Sahlgrens University Hospital, Sweden .
Sahlgrens University Hospital, Sweden .
Sahlgrens University Hospital, Sweden .
Chalmers, Sweden .
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2013 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 19, no 6, 765-774 p.Article in journal (Refereed) Published
Abstract [en]

Background: It is currently unknown whether early immunomodulatory treatment in relapsing-remitting MS (RRMS) can delay the transition to secondary progression (SP). less thanbrgreater than less thanbrgreater thanObjective: To compare the time interval from onset to SP in patients with RRMS between a contemporary cohort, treated with first generation disease modifying drugs (DMDs), and a historical control cohort. less thanbrgreater than less thanbrgreater thanMethods: We included a cohort of contemporary RRMS patients treated with DMDs, obtained from the Swedish National MS Registry (disease onset between 1995-2004, n = 730) and a historical population-based incidence cohort (onset 1950-64, n = 186). We retrospectively analyzed the difference in time to SP, termed the "period effect" within a 12-year survival analysis, using Kaplan-Meier and Cox regression analysis. less thanbrgreater than less thanbrgreater thanResults: We found that the "period" affected the entire severity spectrum. After adjusting for onset features, which were weaker in the contemporary material, as well as the therapy initiation time, the DMD-treated patients still exhibited a longer time to SP than the controls (hazard ratios: men, 0.32; women, 0.53). less thanbrgreater than less thanbrgreater thanConclusion: Our results showed there was a longer time to SP in the contemporary subjects given DMD. Our analyses suggested that this effect was not solely driven by the inclusion of benign cases, and it was at least partly due to the long-term immunomodulating therapy given.

Place, publisher, year, edition, pages
SAGE Publications (UK and US) , 2013. Vol. 19, no 6, 765-774 p.
Keyword [en]
Disease-modifying drugs, disease progression, disease severity, epidemiology, multiple sclerosis, relapsing-remitting multiple sclerosis, secondary progressive multiple sclerosis, Sweden, time to progression
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-93965DOI: 10.1177/1352458512463764ISI: 000318637900011OAI: diva2:628282

Funding Agencies|Swedish||Gothenburg Multiple Sclerosis Societies||Bayer Schering Pharma||Biogen Idec||Novartis||Sanofi-Aventis||BiogenIdec||Merck-Serono||Bayer-Schering||Teva||Swedish Research Council||Gothenburg Societies of the Neurologically Disabled||

Available from: 2013-06-13 Created: 2013-06-13 Last updated: 2014-10-30

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Dahle, CharlotteLandtblom, Anne-MarieVrethem, Magnus
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Clinical ImmunologyFaculty of Health SciencesDepartment of Clinical Immunology and Transfusion MedicineNeurologyDepartment of Neurology
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Multiple Sclerosis
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