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A possible association between panic disorder and a polymorphism in the preproghrelin gene
University of Gothenburg, Sweden .
University of Gothenburg, Sweden .
Chalmers, Sweden .
University of Gothenburg, Sweden .
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2013 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 206, no 1, 22-25 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to investigate whether polymorphisms in the preproghrelin gene are associated with anxiety disorders, such as panic disorder, in humans. Panic disorder is a severe anxiety disorder, characterized by sudden attacks of intense fear or anxiety in combination with somatic symptoms. The preproghrelin gene codes for two gut-derived circulating peptides that have been linked to anxiety-like behaviour in rodents: ghrelin (an orexigenic, pro-obesity hormone) and obestatin. In the present study, we genotyped three missense mutations in the preproghrelin gene in 215 patients suffering from panic disorder and in 451 controls. The A allele of the rs4684677 polymorphism was significantly associated with panic disorder, while there were no significant associations with the two other polymorphisms studied. We conclude that the rs4684677 (Gln90Leu) polymorphism in the preproghrelin gene may be associated with increased risk of panic disorder. It will be important to confirm these findings in additional panic disorder patient groups.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 206, no 1, 22-25 p.
Keyword [en]
Ghrelin, Obestatin, SNP, Anxiety, rs4684677, Gln90Leu, Panic disorder
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-93863DOI: 10.1016/j.psychres.2012.09.051ISI: 000317442900004OAI: diva2:627340

Funding Agencies|Swedish Research Council for Medicine|2009-S266|European Commission|FP7-HEALTH-2009-241592FP7-KBBE-2009-3-245009FP7-KBBE-2010-4-266408|FOU/ALF Goteborg|ALFGBG-138741|Swedish Foundation for Strategic Research|A305-188|

Available from: 2013-06-11 Created: 2013-06-11 Last updated: 2014-11-13

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Sjödin, Ingemar
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