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Tailoring interactions betweendegradable polymers and proteins,exploiting nanodiamond particlesand Quartz Crystal Microbalance
KTH, School of Technology and Health (STH).
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Quartz Crystal Microbalance (QCM) is a sensitive and effective technique to analyze mass changes at the interface between a solid material and a liquid environment. In this Master thesis, QCM was employed for evaluating the interactions between selected degradable polymers and nanodiamond particles (nDP), fibronectin and the growth factor BMP-2.

 

Many parameters must be adapted to allow QCM measurements involving degradable polymers. These parameters were then tailored to allow QCM measurements with PLA, poly(LLA-co-CL), poly(TMC-D-LA) and PS.

 

Moreover, QCM provides quantitative measurements of protein adsorption on degradable polymers. The behavior of PLA and poly(LLA-co-CL) was further evaluated and compared with respect to protein adsorption. This behavior was demonstrated to be different for the two polymers considered and to be dependent on protein concentration in solution.

 

Eventually, exploiting QCM it was also possible to assess the relationship between nDP and the adsorption of fibronectin and BMP-2 onto PLA and poly(LLA-co-CL).

Place, publisher, year, edition, pages
2013. , 114 p.
Keyword [en]
Quartz Crystal Microbalance, degradable polymers, polylactide, fibronectin, nanodiamond particles
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-123148OAI: oai:DiVA.org:kth-123148DiVA: diva2:624871
External cooperation
KTH School of Chemical Science and Engineering
Subject / course
Medical Engineering
Educational program
Master of Science - Medical Engineering
Supervisors
Examiners
Available from: 2016-11-30 Created: 2013-06-03 Last updated: 2016-11-30Bibliographically approved

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