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Prognostic impact of human papilloma virus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.
Örebro University, School of Medicine, Örebro University, Sweden. Örebro University Hospital, Region Örebro County, Örebro, Sweden.ORCID iD: 0000-0003-2317-5738
Örebro University Hospital, Region Örebro County, Örebro, Sweden.
Örebro University Hospital, Region Örebro County, Örebro, Sweden.ORCID iD: 0000-0002-5063-631X
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2013 (English)In: Gynecologic Oncology, ISSN 0090-8258, E-ISSN 1095-6859, Vol. 129, no 2, p. 406-411Article in journal (Refereed) Published
Abstract [en]

Objective

The objectives of this study are to investigate the human papilloma virus (HPV) distribution in vaginal cancer and to evaluate HPV-genotype as well as HPV16-variant impact on prognosis.

Methods

Sixty-nine patients diagnosed with primary vaginal carcinoma (1975-2002) were included in the study. Detection of twelve high-risk HPV (hr HPV) and two low-risk HPV (lr HPV) was performed with realtime-PCR. Samples positive for HPV-16 were analyzed for variants in the E6-gene with PCR and pyrosequencing.

Results

53.6% (37/69) of the tumors were found to be HPV-positive, mostly for HPV-16 (N=26). Other HPV-types were HPV-18 (N=2), HPV-31 (N=2), HPV-33 (N=2), HPV-45 (N=1), HPV-52 (N=2), HPV-56 (N=1) and HPV-58 (N=1). Only European subtypes of HPV-16 were represented and the two most common HPV-16-variants were E-p (N=13) and E-G350 (N=11). Patients with HPV-positive tumors (N=37) had a significantly (log-rank test=3341; p = 0.0008) superior 5-year overall survival rate as well as cancer-specific survival rate and progression-free survival rate (p = 0.0002; p = 0.0004), compared with patients with HPV-negative tumors (N=32). Interestingly, patients with HPV-16-positive tumors had a superior overall survival compared with patients with tumors containing other HPV-genotypes. In a Cox proportional multivariate analysis age, tumor size, and HPV-status were independent and significant prognostic factors with regard to overall survival rate.

Conclusions

HPV-status is of prognostic importance in vaginal carcinoma and varies with viral genotype. In this era of HPV-vaccination, genotypes other than those included in the vaccination program could still lead to vaginal carcinoma with unfavorable prognosis.

Place, publisher, year, edition, pages
2013. Vol. 129, no 2, p. 406-411
Keywords [en]
Vaginal carcinoma, Human papilloma virus, HPV-16-variants, Prognosis
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-29270DOI: 10.1016/j.ygyno.2013.02.004ISI: 000318058600024PubMedID: 23402906Scopus ID: 2-s2.0-84876292443OAI: oai:DiVA.org:oru-29270DiVA, id: diva2:624343
Available from: 2013-05-31 Created: 2013-05-31 Last updated: 2018-05-18Bibliographically approved
In thesis
1. Characterization of HPV-induced vaginal and vulvar carcinoma
Open this publication in new window or tab >>Characterization of HPV-induced vaginal and vulvar carcinoma
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2014. p. 83
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 112
Keywords
vaginal carcinoma, vulvar carcinoma, HPV, integration, methylation, genotyping
National Category
Obstetrics, Gynecology and Reproductive Medicine Cancer and Oncology
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-38173 (URN)978-91-7529-052-2 (ISBN)
Public defence
2014-12-19, Universitetssjukhuset, Wilandersalen, Södra Grev Rosengatan, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2014-10-27 Created: 2014-10-27 Last updated: 2017-10-17Bibliographically approved

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Lillsunde-Larsson, GabriellaHelenius, GiselaAndersson, SörenSorbe, BengtKarlsson, Mats G.
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School of Health and Medical Sciences, Örebro University, SwedenÖrebro University HospitalSchool of Medicine, Örebro University, Sweden
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Gynecologic Oncology
Obstetrics, Gynecology and Reproductive Medicine

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