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Polycyclic aromatic hydrocarbons (PAHs) reduce hepatic beta-oxidation of fatty acids in chick embryos
Örebro University, School of Science and Technology. (MTM)ORCID iD: 0000-0001-7338-2079
Örebro University, School of Health and Medical Sciences. (Biomedicin)ORCID iD: 0000-0001-8102-1804
Örebro University, School of Science and Technology. (MTM)
Örebro University, School of Science and Technology. (MTM)
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2013 (English)In: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 20, no 3, p. 1881-1888Article in journal (Refereed) Published
Abstract [en]

Polycyclic aromatic hydrocarbons (PAHs) are widespread fused-ring contaminants formed during incomplete combustion of almost all kind of organic materials from both natural and anthropogenic sources. Some PAHs have been shown to be carcinogenic to humans, and a wide range of PAHs are found in wildlife all around the globe including avian species. The purpose of this project was to assess the effects of a standard mixture of 16 PAHs (United States Environmental Protection Agency) on the hepatic fatty acid beta-oxidation in chicken embryos (Gallus gallus domesticus) exposed in ovo. The hepatic beta-oxidation was measured using a tritium release assay with [9,10-H-3]-palmitic acid (16:0) as substrate. Treated groups were divided into groups of 0.05, 0.1, 0.3, 0.5, and 0.8 mg PAHs/kg egg weight. The hepatic beta-oxidation was reduced after exposure in ovo to the 16 PAHs mixture compared to control. The mechanisms causing reduced fatty acid oxidation in the present study are unclear, however may be due to deficient membrane structure, the functionality of enzymes controlling the rate of fatty acid entering into the mitochondria, or complex pathways connected to endocrine disruption. To the best of our knowledge, this is the first time a PAH-caused reduction of hepatic beta-oxidation of fatty acids in avian embryos has been observed. The implication of this finding on risk assessment of PAH exposure in avian wildlife remains to be determined.

Place, publisher, year, edition, pages
2013. Vol. 20, no 3, p. 1881-1888
National Category
Natural Sciences
Research subject
Enviromental Science; Biology
Identifiers
URN: urn:nbn:se:oru:diva-29081DOI: 10.1007/s11356-012-1418-7ISI: 000315442500065PubMedID: 23274806OAI: oai:DiVA.org:oru-29081DiVA, id: diva2:622272
Projects
SOILTOX
Funder
Knowledge FoundationAvailable from: 2013-05-21 Created: 2013-05-21 Last updated: 2018-05-17Bibliographically approved
In thesis
1. Development of bioassays for risk assessment of PAHs and PFASs in the environment
Open this publication in new window or tab >>Development of bioassays for risk assessment of PAHs and PFASs in the environment
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2013. p. 72
Series
Örebro Studies in Biology, ISSN 1650-8793 ; 8
National Category
Environmental Sciences Biological Sciences
Research subject
Biology
Identifiers
urn:nbn:se:oru:diva-30068 (URN)978-91-7668-965-3 (ISBN)
Public defence
2013-10-11, Hörsalen, Billbergska huset, Örebro universitet, Fakultetsgatan 1, Örebro, 10:00 (English)
Opponent
Supervisors
Available from: 2013-07-30 Created: 2013-07-30 Last updated: 2017-10-17Bibliographically approved

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Engwall, MagnusVenizelos, NikolaosWestman, OlaLarsson, MariaNordén, MarcusJohansson, Jessica
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School of Science and TechnologySchool of Health and Medical SciencesSchool of Health and Medical Sciences, Örebro University, Sweden
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Environmental science and pollution research international