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Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease
Institute of Dentistry, University of Helsinki.
Institute of Dentistry, University of Helsinki.
Institute of Dentistry, University of Helsinki.
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap. Kristianstad University, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet.ORCID iD: 0000-0002-3620-5978
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2013 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 40, no 6, p. 583-590Article in journal (Refereed) Published
Abstract [en]

Aim We investigated the association between angiographically verified coronary artery disease (CAD) and subgingival Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola. Materials and Methods The cross-sectional study population (n = 445) comprised 171 (38.4%) patients with Stable CAD, 158 (35.5%) with acute coronary syndrome (ACS) and 116 (26.1%) with no significant CAD (No CAD). All patients participated in clinical and radiological oral health examinations. Pooled subgingival bacterial samples were analysed by checkerboard DNA–DNA hybridization assays. Results In all study groups, the presence of P. gingivalis, T. forsythia and T. denticola indicated a significant (p ≤ 0.001) linear association with the extent of alveolar bone loss (ABL), but A. actinomycetemcomitans did not (p = 0.074). With a threshold level of bacterial cells 1 × 105 A. actinomycetemcomitans was significantly more prevalent in the Stable CAD group (42.1%) compared to the No CAD group (30.2%) (p = 0.040). In a multi-adjusted logistic regression analysis using this threshold, A. actinomycetemcomitans positivity associated with Stable CAD (OR 1.83, 95% CI 1.00–3.35, p = 0.049), but its level or levels of other bacteria did not. Conclusions The presence of subgingival A. actinomycetemcomitans associates with an almost twofold risk of Stable CAD independently of alveolar bone loss.

Place, publisher, year, edition, pages
2013. Vol. 40, no 6, p. 583-590
Keywords [en]
Aggregatibacter actinomycetemcomitans, angiography, coronary artery disease, DNA–DNA hybridization, subgingival bacteria
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-10498DOI: 10.1111/jcpe.12098ISI: 000318514600003PubMedID: 23521427OAI: oai:DiVA.org:hkr-10498DiVA, id: diva2:620226
Available from: 2013-05-08 Created: 2013-05-08 Last updated: 2017-12-06Bibliographically approved

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Persson, G. Rutger
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Avdelningen för HälsovetenskapForskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet
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