Polymeric Smart Coating Strategy for Titanium Implants
2014 (English)In: Advanced Engineering Materials, ISSN 1438-1656, E-ISSN 1527-2648, Vol. 16, no 11, 1340-1350 p.Article in journal (Refereed) Published
Hyaluronan based hydrogel coatings can mimic extracellular matrix components and incorporate growth factors that can be released during a progressive degradation while new tissue regenerates. This paper describes a structural characterization of a hydrogel coating made of modified hyaluronan polymers and how these coatings interact with bone morphogenetic protein-2 (BMP-2). Quartz crystal microbalance and neutron reflectivity measurements were used for in-situ, real-time measurements of the adsorption properties of polymers and proteins on smooth titanium oxide surfaces that mimic implant products in orthopedics. The adsorption of BMP-2 on a bare titanium oxide surface is compared to that on titanium oxide coated with different chemically modified hyaluronan, the most important being hyaluronan with bisphosphonate groups (HA-BP). The subsequent release of the BMP-2 from these hydrogel coatings could be triggered by calcium ions. The amount of adsorbed protein on the surfaces as well as the amount of released protein both depend on the type of hyaluronan coating. We conclude that HA-BP coated titanium oxide surfaces provide an excellent material for growth factor delivery in-vivo.
Place, publisher, year, edition, pages
2014. Vol. 16, no 11, 1340-1350 p.
Biomaterials Science Polymer Chemistry Polymer Technologies Materials Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-197816DOI: 10.1002/adem.201400009ISI: 000344790000004OAI: oai:DiVA.org:uu-197816DiVA: diva2:616400