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Polymeric Smart Coating Strategy for Titanium Implants
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström. Uppsala University, Science for Life Laboratory, SciLifeLab.
Institut Laue-Langevin.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
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2014 (English)In: Advanced Engineering Materials, ISSN 1438-1656, E-ISSN 1527-2648, Vol. 16, no 11, 1340-1350 p.Article in journal (Refereed) Published
Abstract [en]

Hyaluronan based hydrogel coatings can mimic extracellular matrix components and incorporate growth factors that can be released during a progressive degradation while new tissue regenerates. This paper describes a structural characterization of a hydrogel coating made of modified hyaluronan polymers and how these coatings interact with bone morphogenetic protein-2 (BMP-2). Quartz crystal microbalance and neutron reflectivity measurements were used for in-situ, real-time measurements of the adsorption properties of polymers and proteins on smooth titanium oxide surfaces that mimic implant products in orthopedics. The adsorption of BMP-2 on a bare titanium oxide surface is compared to that on titanium oxide coated with different chemically modified hyaluronan, the most important being hyaluronan with bisphosphonate groups (HA-BP). The subsequent release of the BMP-2 from these hydrogel coatings could be triggered by calcium ions. The amount of adsorbed protein on the surfaces as well as the amount of released protein both depend on the type of hyaluronan coating. We conclude that HA-BP coated titanium oxide surfaces provide an excellent material for growth factor delivery in-vivo.

Place, publisher, year, edition, pages
2014. Vol. 16, no 11, 1340-1350 p.
National Category
Biomaterials Science Polymer Chemistry Polymer Technologies Materials Chemistry
URN: urn:nbn:se:uu:diva-197816DOI: 10.1002/adem.201400009ISI: 000344790000004OAI: diva2:616400
Available from: 2013-04-16 Created: 2013-04-04 Last updated: 2014-12-22Bibliographically approved
In thesis
1. Relating the Bulk and Interface Structure of Hyaluronan to Physical Properties of Future Biomaterials
Open this publication in new window or tab >>Relating the Bulk and Interface Structure of Hyaluronan to Physical Properties of Future Biomaterials
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This dissertation describes a structural investigation of hyaluronan (HA) with neutron scattering techniques. HA is a natural biopolymer and one of the major components of the extracellular matrix, synovial fluid, and vitreous humor.  It is used in several biomedical applications like tissue engineering, drug delivery, and treatment of osteoarthritis. Although HA is extensively studied, very little is known about its three-dimensional conformation and how it interacts with ions and other molecules. The study aims to understand the bulk structure of a cross-linked HA hydrogel, as well as the conformational arrangement of HA at solid-liquid interfaces. In addition, the structural changes of HA are investigated by simulation of physiological environments, such as changes in ions, interactions with nanoparticles, and proteins etc. Small-angle neutron scattering and neutron reflectivity are the two main techniques applied to investigate the nanostructure of hyaluronan in its original, hydrated state.

The present study on hydrogels shows that they possess inhomogeneous structures best described with two correlation lengths, one of the order of a few nanometers and the other in the order of few hundred nanometers. These gels are made up of dense polymer-rich clusters linked to each other. The polymer concentration and mixing governs the connectivity between these clusters, which in turn determines the viscoelastic properties of the gels. Surface-tethered HA at a solid-liquid interface is best described with a smooth varying density profile. The shape of this profile depends on the immobilization chemistry, the deposition protocol, and the ionic interactions. HA could be suitably modified to enhance adherence to metal surfaces, as well as incorporation of proteins like growth factors with tunable release properties. This could be exploited for surface coating of implants with bioactive molecules. The knowledge gained from this work would significantly help to develop future biomaterials and surface coatings of implants and biomedical devices.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2013. 66 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1043
hyaluronan, structure, bulk, interface, small-angle neutron scattering, neutron reflection, hydrogel, grafting, nanoparticles, protein interactions
National Category
Polymer Chemistry Materials Chemistry
urn:nbn:se:uu:diva-198357 (URN)978-91-554-8669-3 (ISBN)
Public defence
2013-06-05, Häggsalen, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:00 (English)
Available from: 2013-05-15 Created: 2013-04-12 Last updated: 2013-08-30Bibliographically approved

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Berts, IdaOssipov, DmitriFrisk, AndreasRennie, Adrian. R
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