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Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-3587-3568
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences.
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2013 (English)In: Epilepsy & Behavior, ISSN 1525-5050, E-ISSN 1525-5069, Vol. 28, no 1, 26-35 p.Article in journal (Refereed) Published
Abstract [en]

We aimed to study the effect of a potential default mode network (DMN) dysfunction on language performance in epilepsy. Language dysfunction in focal epilepsy has previously been connected to brain damage in language-associated cortical areas. In this work, we studied generalized epilepsy (GE) without focal brain damage to see if the language function was impaired. We used functional magnetic resonance imaging (fMRI) to investigate if the DMN was involved. Eleven persons with GE and 28 healthy controls were examined with fMRI during a sentence-reading task. We demonstrated impaired language function, reduced suppression of DMN, and, specifically, an inadequate suppression of activation in the left anterior temporal lobe and the posterior cingulate cortex, as well as an aberrant activation in the right hippocampal formation. Our results highlight the presence of language decline in people with epilepsy of not only focal but also generalized origin.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 28, no 1, 26-35 p.
Keyword [en]
generalized epilepsy, functional Magnetic Resonance Imaging (fMRI), language performance, sentence reading, verbal fluency, default mode network, hippocampus, temporal lobe, posterior cingulate cortex
National Category
Radiology, Nuclear Medicine and Medical Imaging Neurology
Identifiers
URN: urn:nbn:se:liu:diva-91043DOI: 10.1016/j.yebeh.2013.04.001ISI: 000320423500007PubMedID: 23648277OAI: oai:DiVA.org:liu-91043DiVA: diva2:615917
Available from: 2013-04-12 Created: 2013-04-12 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Mind your Language, All Right? Performance-dependent neural patterns of language
Open this publication in new window or tab >>Mind your Language, All Right? Performance-dependent neural patterns of language
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The main aim of this dissertation was to investigate the difference in neural language patternsrelated to language ability in healthy adults. The focus lies on unraveling the contributions of theright‐hemispheric homologues to Broca’s area in the inferior frontal gyrus (IFG) and Wernicke’s areain the posterior temporal and inferior parietal lobes. The functions of these regions are far from fullyunderstood at present. Two study populations consisting of healthy adults and a small group ofpeople with generalized epilepsy were investigated. Individual performance scores in tests oflanguage ability were correlated with brain activation obtained with functional magnetic resonanceimaging during semantic and word fluency tasks. Performance‐dependent differences were expectedin the left‐hemispheric Broca’s and Wernicke’s area and in their right‐hemispheric counterparts.

PAPER I revealed a shift in laterality towards right‐hemispheric IFG and posterior temporal lobeactivation, related to high semantic performance. The whole‐brain analysis results of PAPER IIrevealed numerous candidate regions for language ability modulation. PAPER II also confirmed thefinding of PAPER I, by showing several performance‐dependent regions in the right‐hemispheric IFGand the posterior temporal lobe.

In PAPER III, a new study population of healthy adults was tested.Again, the right posterior temporal lobe was related to high semantic performance. A decrease in lefthemisphericIFG activation could be linked to high word fluency ability. In addition, task difficultywas modulated. Increased task complexity showed to correlate positively with bilateral IFGactivation.

Lastly, PAPER IV investigated anti‐correlated regions. These regions are commonly knownas the default mode network (DMN) and are normally suppressed during cognitive tasks. It wasfound that people with generalized epilepsy had an inadequate suppression of regions in the DMN,and showed poorer performance in a complex language test. The results point to neural adaptabilityin the IFG and temporal lobe. Decreased left‐lateralization of the IFG and increased rightlateralizationof the posterior temporal lobe are proposed as characteristics of individuals with highlanguage ability.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2013. 56 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1358
Keyword
Language ability, performance, fMRI, functional magnetic resonance imaging, Broca, Wernicke, temporal lobe, inferior frontal gyrus, reading, fluency, lateralization, lateralisation, right hemisphere, performance-dependent, neural activation
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-91053 (URN)978-91-7519-668-8 (ISBN)
Public defence
2013-05-17, Berzeliussalen, Campus US, Linköpings universitet, Linköping, 13:15 (English)
Opponent
Supervisors
Available from: 2013-04-16 Created: 2013-04-12 Last updated: 2014-10-02Bibliographically approved

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Gauffin, Helenavan Ettinger-Veenstra, HeleneLandtblom, Anne-MarieMcAllister, AnitaKarlsson, ThomasEngström, Maria
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Center for Medical Image Science and Visualization (CMIV)NeurologyFaculty of Health SciencesRadiologyDepartment of NeurologySpeech and Language PathologyDepartment of Otorhinolaryngology in LinköpingDisability ResearchFaculty of Arts and Sciences
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