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ZBED Evolution: Repeated Utilization of DNA Transposons as Regulators of Diverse Host Functions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2013 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 3, e59940- p.Article in journal (Refereed) Published
Abstract [en]

ZBED genes originate from domesticated hAT DNA transposons and encode regulatory proteins of diverse function in vertebrates. Here we reveal the evolutionary relationship between ZBED genes and demonstrate that they are derived from at least two independent domestication events in jawed vertebrate ancestors. We show that ZBEDs form two monophyletic clades, one of which has expanded through several independent duplications in host lineages. Subsequent diversification of ZBED genes has facilitated regulation of multiple diverse fundamental functions. In contrast to known examples of transposable element exaptation, our results demonstrate a novel unprecedented capacity for the repeated utilization of a family of transposable element-derived protein domains sequestered as regulators during the evolution of diverse host gene functions in vertebrates. Specifically, ZBEDs have contributed to vertebrate regulatory innovation through the donation of modular DNA and protein interacting domains. We identify that C7ORF29, ZBED2, 3, 4, and ZBEDX form a monophyletic group together with ZBED6, that is distinct from ZBED1 genes. Furthermore, we show that ZBED5 is related to Buster DNA transposons and is phylogenetically separate from other ZBEDs. Our results offer new insights into the evolution of regulatory pathways, and suggest that DNA transposons have contributed to regulatory complexity during genome evolution in vertebrates.

Place, publisher, year, edition, pages
2013. Vol. 8, no 3, e59940- p.
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Evolutionary Biology
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URN: urn:nbn:se:uu:diva-197585DOI: 10.1371/journal.pone.0059940ISI: 000316549400098ISBN: 1932-6203 (Electronic) 1932-6203 (Linking) (print)OAI: oai:DiVA.org:uu-197585DiVA: diva2:613565
Available from: 2013-03-28 Created: 2013-03-28 Last updated: 2017-12-06Bibliographically approved

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Publisher's full texthttp://www.ncbi.nlm.nih.gov/pubmed/23533661

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Hayward, AlexanderAndersson, LeifJern, Patric
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