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Ligand binding properties of human galanin receptors
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).ORCID iD: 0000-0002-7115-9751
2013 (English)In: Molecular membrane biology, ISSN 0968-7688, E-ISSN 1464-5203, Vol. 30, no 2, 206-216 p.Article in journal (Refereed) Published
Abstract [en]

The galanin receptor family comprises of three members, GalR1, GalR2 and GalR3, all belonging to the G-protein-couple receptor superfamily. All three receptors bind the peptide hormone galanin, but show distinctly different binding properties to other molecules and effects on intracellular signaling. To gain insight on the molecular basis of receptor subtype specificity, we have generated a three-dimensional model for each of the galanin receptors based on its homologs in the same family. We found significant differences in the organization of the binding pockets among the three types of receptors, which might be the key for specific molecular recognition of ligands. Through docking of fragments of the galanin peptide and a number of ligands, we investigated the involvement of transmembrane and loop residues in ligand interaction.

Place, publisher, year, edition, pages
2013. Vol. 30, no 2, 206-216 p.
Keyword [en]
Galanin receptors, GPCR modeling, ligand binding
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-88708DOI: 10.3109/09687688.2012.750384ISI: 000315183900010OAI: oai:DiVA.org:su-88708DiVA: diva2:612830
Funder
EU, FP7, Seventh Framework Programme, 201924Swedish Research Council
Note

AuthorCount:3;

Available from: 2013-03-25 Created: 2013-03-25 Last updated: 2017-12-06Bibliographically approved

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