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The effects on depression of Internet-administered behavioural activation and physical exercise with treatment rationale and relapse prevention: study protocol for a randomised controlled trial
Department of Psychology, Stockholm University, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden and Department of Psychology, Umeå University, Umeå, Sweden .
Martell Behavioral Activation Research Consulting and Department of Psychology, University of Wisconsin, Milwaukee, WI, USA.
Department of Psychology, Umeå University, Umeå, Sweden.
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2013 (English)In: Trials, ISSN 1745-6215, Vol. 14, no 35Article in journal (Refereed) Published
Abstract [en]


Despite their potential as low-threshold, low-cost and high-flexibility treatments of depression, behavioural activation and physical exercise have not yet been directly compared. This study will examine the effects of these interventions, administered via the Internet. The added effect of providing a treatment rationale will also be studied, as well as a relapse prevention program featuring cognitive behavioural therapy components.


This randomised controlled trial will include 500 participants meeting the diagnostic criteria for major depression, recruited in multiple cycles and randomised to either a waiting list control group with delayed treatment, or one of the four treatment groups: (1) physical exercise without a clear treatment rationale; (2) physical exercise with treatment rationale; (3) behavioural activation with treatment rationale; or (4) behavioural activation without a clear treatment rationale. Post treatment, half of the participants will be offered a relapse prevention program. Primary outcome measure will be the Patient Health Questionnaire 9-item. Secondary measures include diagnostic criteria for depression, as well as self-reported anxiety, physical activity and quality of life. Measurements - done via telephone and the Internet - will be collected pre-treatment, weekly during treatment period, immediately post treatment and then monthly during a 24-month follow-up period.


The results of this study will constitute an important contribution to the body of knowledge of the respective interventions. Limitations are discussed.

Trial registration NCT01619930

Place, publisher, year, edition, pages
BioMed Central , 2013. Vol. 14, no 35
Keyword [en]
Depression, Behavioural activation, Physical exercise, Treatment rationale, Relapse prevention, Internet-administered
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-90203DOI: 10.1186/1745-6215-14-35ISI: 000315119400001OAI: diva2:612356

Funding Agencies|Swedish Council for Working Life and Social Research|2011-0477|

Available from: 2013-03-28 Created: 2013-03-21 Last updated: 2014-11-28Bibliographically approved

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