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Postangioplasty restenosis followed with magnetic resonance imaging in an atherosclerotic rabbit model
Department of Radiology, Oncology, and Radiation Science, Section of Radiology, Uppsala University, Uppsala, Sweden.
Department of Surgery, Uppsala University Hospital, Uppsala, Sweden.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0002-7750-1917
2012 (English)In: International Journal of Biomedical Imaging, ISSN 1687-4188, E-ISSN 1687-4196, Vol. 2012, 747264- p.Article in journal (Refereed) Published
Abstract [en]

Rationale and Objectives. Testing a quantitative, noninvasive method to assess postangioplasty vessel wall changes in an animal model. Material and Methods. Six New Zealand white rabbits were subjected to atherosclerotic injury, including cholesterol-enriched diet, deendothelialization, and percutaneous transluminal angioplasty (PTA) in the distal part of abdominal aorta (four weeks after deendothelialization). The animals were examined with a 1.5T MRI scanner at three times as follows: baseline (six weeks after diet start and two days after PTA) and four weeks and 10 weeks after-PTA. Inflow angiosequence (M2DI) and proton-density-weighted sequence (PDW) were performed to examine the aorta with axial slices. To identify the inner and outer vessel wall boundaries, a dynamic contour algorithm (Gradient Vector Flow Snakes) was applied to the images, followed by calculation of the vessel wall dimensions. The results were compared with histopathological analysis. Results. The wall thickness in the lesion was significantly higher than in the control region at 4 and 10 weeks, reflecting induction of experimentally created after-angioplasty lesion. At baseline, no significant difference between the two regions was present. Conclusions. It is possible to follow the development of vessel wall changes after-PTA with MRI in this rabbit model.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2012. Vol. 2012, 747264- p.
Keyword [en]
CNS, MR imaging, brain, technology assessment, imaging sequences
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-90018DOI: 10.1155/2012/747264PubMedID: 23316216OAI: diva2:611217
Available from: 2013-03-15 Created: 2013-03-15 Last updated: 2014-09-10Bibliographically approved

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Smedby, Örjan
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Center for Medical Image Science and Visualization (CMIV)RadiologyFaculty of Health SciencesDepartment of Radiology in Linköping
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