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Ruling out cardiac failure: Cost-benefit analysis of a sequential testing strategy with NT-proBNP before echocardiography
Department of Clinical Chemistry, Blekinge County Hospital, Sweden.
Department of Clinical Chemistry, Blekinge County Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden.
2013 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 118, no 2, 75-79 p.Article in journal (Refereed) Published
Abstract [en]

Objectives. To estimate the possible economic benefit of a sequential testing strategy with NT-proBNP to reduce the number of echocardiographies.

Methods. Retrospective study in a third-party payer perspective. The costs were calculated from three Swedish counties: Blekinge, Östergötland, and Uppland. Two cut-off levels of NT-proBNP were used: 400 and 300 pg/mL. The cost-effectiveness of the testing strategy was estimated through the short-term cost avoidance and reduction in demand for echocardiographies.

Results. The estimated costs for NT-proBNP tests and echocardiographies per county were reduced by 33%–36% with the 400 pg/mL cut-off and by 28%–29% with the 300 pg/mL cut-off. This corresponded to a yearly cost reduction of approximately €2–5 million per million inhabitants in these counties.

Conclusion. The use of NT-proBNP as a screening test could substantially reduce the number of echocardiographies in the diagnostic work-up of patients with suspected cardiac failure, as well as the associated costs.

Place, publisher, year, edition, pages
Informa Healthcare, 2013. Vol. 118, no 2, 75-79 p.
Keyword [en]
Cost, echocardiography, health economics, heart failure, laboratory test, NT-proBNP
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-89968DOI: 10.3109/03009734.2012.751471ISI: 000317486000002PubMedID: 23230860OAI: diva2:610607
Available from: 2013-03-12 Created: 2013-03-12 Last updated: 2013-11-04

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