Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The potential of dual-energy computed tomography for quantitative decomposition of soft tissues to water, protein and lipid in brachytherapy
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-1257-2383
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-9072-2204
Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-0209-498X
2013 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 58, no 4, 771-785 p.Article in journal (Refereed) Published
Abstract [en]

Dosimetric accuracy of radiation treatment planning in brachytherapy depends on knowledge of tissue composition. It has been speculated that soft tissues can be decomposed to water, lipid and protein. The aim of our work is to evaluate the accuracy of such tissue decomposition. Selected abdominal soft tissues, whose average elemental compositions were taken from literature, were decomposed using dual energy computed tomography to water, lipid and protein via the three-material decomposition method. The quality of the decomposition was assessed using relative differences between (i) mass energy absorption and (ii) mass energy attenuation coefficients of the analyzed and approximated tissues. It was found that the relative differences were less than 2% for photon energies larger than 10 keV. The differences were notably smaller than the ones for water as the transport and dose scoring medium. The choice of the water, protein and lipid triplet resulted in negative elemental mass fractions for some analyzed tissues. As negative elemental mass fractions cannot be used in general purpose particle transport computer codes using the Monte Carlo method, other triplets should be used for the decomposition. These triplets may further improve the accuracy of the approximation as the differences were mainly caused by the lack of high-Z materials in the water, protein and lipid triplet.

Place, publisher, year, edition, pages
Institute of Physics , 2013. Vol. 58, no 4, 771-785 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-89734DOI: 10.1088/0031-9155/58/4/771ISI: 000314396800004OAI: oai:DiVA.org:liu-89734DiVA: diva2:609387
Note

Funding Agencies|Swedish Cancer Society (Cancerfonden)|100 512|

Available from: 2013-03-05 Created: 2013-03-05 Last updated: 2017-12-06

Open Access in DiVA

fulltext(297 kB)769 downloads
File information
File name FULLTEXT01.pdfFile size 297 kBChecksum SHA-512
ec49adb48e99767d5ce7862a09da01fb804c4253e448c9997f4e53d3ea46a1bd5f77cf6d7c7afc9b6b5b03ca3b9670e3f5fcce5a0d658b0d91aa82c051ecce6b
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Malusek, AlexandrKarlsson, MattiasMagnusson, MariaAlm Carlsson, Gudrun
By organisation
Radiation PhysicsFaculty of Health SciencesDivision of Radiological SciencesComputer VisionThe Institute of TechnologyDepartment of Radiation Physics
In the same journal
Physics in Medicine and Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 769 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 291 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf