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Background levels and diurnal variations of hydrogen cyanide in breath and emitted from skin
University of Helsinki. (Laboratory of Physical Chemistry)ORCID iD: 0000-0002-5065-7786
2011 (English)In: Journal of Breath Research, ISSN 1752-7163, Vol. 5, no 4, 046004Article in journal (Refereed) Published
Abstract [en]

The hydrogen cyanide (HCN) concentration in exhaled human breath and skin gas samples collected with different sampling techniques was measured using near-infrared cavity ring-down spectroscopy. The median baseline HCN concentrations in samples provided by 19 healthy volunteers 2-4 h after the last meal depended on the employed sampling technique: 6.5 parts per billion by volume (ppbv) in mixed (dead space and end-tidal) mouth-exhaled breath collected to a gas sampling bag, 3.9 ppbv in end-tidal mouth-exhaled breath, 1.3 ppbv in end-tidal nose-exhaled breath, 1.0 ppbv in unwashed skin and 0.6 ppbv in washed skin samples. Diurnal measurements showed that elevated HCN levels are to be expected in mouth-exhaled breath samples after food and drink intake, which suggests HCN generation in the oral cavity. The HCN concentrations in end-tidal nose-exhaled breath and skin gas samples were correlated, and it is concluded that these concentrations best reflect systemic HCN levels.

Place, publisher, year, edition, pages
Bristol, UK: Institute of Physics Publishing (IOPP), 2011. Vol. 5, no 4, 046004
Keyword [en]
tube mass-spectrometry, pseudomonas-aeruginosa, volatile compounds, exhaled breath, cavity ring, identification, spectroscopy, ventilation, ethylene, hcn
National Category
Medical Engineering Atom and Molecular Physics and Optics Medicinal Chemistry Medical Biotechnology Environmental Health and Occupational Health
URN: urn:nbn:se:umu:diva-64494DOI: 10.1088/1752-7155/5/4/046004ISI: 000298182800004OAI: diva2:601750

863QS Times Cited:2 Cited References Count:39

Available from: 2013-01-30 Created: 2013-01-30 Last updated: 2015-03-12Bibliographically approved

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