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Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
Abo Akad University, Finland .
Abo Akad University, Finland Maharaja Sayajirao University of Baroda, India .
Abo Akad University, Finland .
Linköping University, Department of Physics, Chemistry and Biology, Nanostructured Materials. Linköping University, The Institute of Technology.
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2012 (English)In: Nanoscale Research Letters, ISSN 1931-7573, E-ISSN 1556-276X, Vol. 7, no 358Article in journal (Refereed) Published
Abstract [en]

In nanomedicine, physicochemical properties of the nanocarrier affect the nanoparticles pharmacokinetics and biodistribution, which are also decisive for the passive targeting and nonspecific cellular uptake of nanoparticles. Size and surface charge are, consequently, two main determining factors in nanomedicine applications. Another important parameter which has received much less attention is the morphology (shape) of the nanocarrier. In order to investigate the morphology effect on the extent of cellular internalization, two similarly sized but differently shaped rod-like and spherical mesoporous silica nanoparticles were synthesized, characterized and functionalized to yield different surface charges. The uptake in two different cancer cell lines was investigated as a function of particle shape, coating (organic modification), surface charge and dose. According to the presented results, particle morphology is a decisive property regardless of both the different surface charges and doses tested, whereby rod-like particles internalized more efficiently in both cell lines. At lower doses whereby the shape-induced advantage is less dominant, charge-induced effects can, however, be used to fine-tune the cellular uptake as a prospective secondary uptake regulator for tight dose control in nanoparticle-based drug formulations.

Place, publisher, year, edition, pages
SpringerOpen , 2012. Vol. 7, no 358
Keyword [en]
mesoporous silica nanoparticles, surface functionalization, rod-shaped particles, surface charge, cellular internalization, nanomedicine
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-87470DOI: 10.1186/1556-276X-7-358ISI: 000312587000001OAI: diva2:589459

Funding Agencies|Academy of Finland|140193140759126161137101|Centre of Excellence for Functional Materials||Centre for International Mobility India-Finland Fellowship||Sigrid Juselius Foundation||Nanolith Sverige AB||FP7 IRG||AAU Center of Excellence||Liv och Halsa Foundation||

Available from: 2013-01-18 Created: 2013-01-18 Last updated: 2014-09-11

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