Redox events in HTLV-1 tax-induced apoptotic T-cell death
2002 (English)In: Antioxidants and Redox Signaling, ISSN 1523-0864, E-ISSN 1557-7716, Vol. 4, no 3, 471-477 p.Article in journal (Refereed) Published
A number of studies implicate reactive oxygen intermediates in the induction of DNA damage and apoptosis. Recent studies suggest that the human T-cell leukemia virus type I (HTLV-1) Tax protein induces oxidative stress and apoptotic T-cell death. Activation of the T-cell receptor/CD3 pathway enhances the Tax-mediated oxidative and apoptotic effects. Tax-mediated apoptosis and oxidative stress as well as activation of nuclear factor-kappaB can be potently suppressed by antioxidants. This review focuses on Tax-dependent changes in the intracellular redox status and their role in Tax-mediated DNA damage and apoptosis. The relevance of these observations to HTLV-1 virus-mediated T-cell transformation and leukemogenesis are discussed.
Place, publisher, year, edition, pages
Mary Ann Liebert, Inc. publishers , 2002. Vol. 4, no 3, 471-477 p.
dna-repair, gene-expression, human thioredoxin, leukemia-virus, nf-kappa-b, oxidative stress, prooxidant state, Signaling pathway, transcription factors, virus type-i
Biochemistry and Molecular Biology Cell Biology
IdentifiersURN: urn:nbn:se:liu:diva-87010DOI: 10.1089/15230860260196263ISI: 000176633600012PubMedID: 12215214OAI: oai:DiVA.org:liu-87010DiVA: diva2:584228