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Apoptin, a tumor-selective killer
Interfaculty Institute for Biochemistry, University of Tübingen, Germany; BioApplications Enterprises, Winnipeg, MB, Canada.
Department of Immunology, Lerner Research Institute, Cleveland, USA.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.
Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Show others and affiliations
2009 (English)In: Biochimica et Biophysica Acta. Molecular Cell Research, ISSN 0167-4889, E-ISSN 1879-2596, Vol. 1793, no 8, 1335-1342 p.Article, review/survey (Refereed) Published
Abstract [en]

Apoptin, a small protein from chicken anemia virus, has attracted great attention, because it specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. In normal cells, apoptin resides in the cytoplasm, whereas in cancerous cells it translocates into the nucleus. The nuclear translocation of apoptin is largely controlled by its phosphorylation. In tumor cells, apoptin causes the nuclear accumulation of survival kinases including Akt and is phosphorylated by CDK2. Thereby, apoptin redirects survival signals into cell death responses. Apoptin also binds as a multimeric complex to DNA and interacts with several nuclear targets, such as the anaphase-promoting complex, resulting in a G2/M phase arrest. The proapoptotic signal of apoptin is then transduced from the nucleus to cytoplasm by Nur77, which triggers a p53-independent mitochondrial death pathway. In this review, we summarize recent discoveries of apoptin's mechanism of action that might provide intriguing insights for the development of novel tumor-selective anticancer drugs.

Place, publisher, year, edition, pages
2009. Vol. 1793, no 8, 1335-1342 p.
Keyword [en]
Apoptin; Apoptosis; CDK2; Nur77; Tumor
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Biochemistry and Molecular Biology Cell Biology
Identifiers
URN: urn:nbn:se:liu:diva-86909DOI: 10.1016/j.bbamcr.2009.04.002ISI: 000268975400001OAI: oai:DiVA.org:liu-86909DiVA: diva2:583084
Note

Invited Review

Available from: 2013-01-07 Created: 2013-01-07 Last updated: 2017-12-06

Open Access in DiVA

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