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New, exciting developments in experimental therapies in the early 21st century
Interfaculty Institute for Biochemistry, University of Tübingen, Germany; BioApplications Enterprises, Winnipeg, MB, Canada.ORCID iD: 0000-0001-9518-1411
2009 (English)In: European Journal of Pharmacology, ISSN 0014-2999, E-ISSN 1879-0712, Vol. 625, no 1-3, 1-5 p.Article, review/survey (Refereed) Published
Abstract [en]

The volume is dedicated to novel anticancer strategies. Our aim was to identify and cover novel, emerging anticancer approaches that will form the backbone of future, more efficient anticancer therapies. Beside classical “small molecule” pharmacologic approaches, or radiotherapy, the review introduces cancer stem cell, their markers involved in metastasizing, it covers various immunotherapeutic experimental treatment, inclusive anticancer cellular vaccines, as well as computational strategies aimed at modeling of cancer therapy or at least the intermolecular interactions between drug and the cellular target. Large portion of the volume is dedicated to various targeted anticancer approaches that involve either novel targets within cancer cells (i.e. endoplasmic reticulum and protein folding, or cell–cell adherence), or novel molecules like TRAIL and another human cytokine mda-7/IL-24, Brevinin-2R, viral proteins R4orf4, NS1, and apoptin, HAMLET, onconase, and other molecules. Significant part of the review is also dedicated towards targeting of receptor-initiated and intracellular kinase cascades that are often upregulated in various malignancies. We hope that the variety of topics highlighted in this volume will foster cross-discipline collaborations, so necessary for the development of novel therapeutics.

Place, publisher, year, edition, pages
Elsevier, 2009. Vol. 625, no 1-3, 1-5 p.
Keyword [en]
Bystander effect; Epidermal growth factor; DNMT; Her2/neu; HDAC; RAGE; S100A8/A9; SDF-1; Single nucleotide polymorphism
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Biochemistry and Molecular Biology
URN: urn:nbn:se:liu:diva-86908DOI: 10.1016/j.ejphar.2009.10.008ISI: 000272748300001OAI: diva2:583069
Available from: 2013-01-07 Created: 2013-01-07 Last updated: 2013-09-03

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Los, Marek Jan
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