Epstein-Barr virus antibodies and vitamin D in prospective multiple sclerosis biobank sampels
2013 (English)In: Multiple Sclerosis Journal, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 19, no 12, 1587-1591 p.Article in journal (Refereed) Published
Background: Increased antibody reactivity against Epstein-Barr Nuclear Antigen-1 (EBNA-1) has been associated with an increased risk for MS, and high levels of 25-Hydroxyvitamin D (25[OH]D) have been associated with a lower risk for MS. Interaction between these two factors has been proposed.
Objectives: To examine the association between antibody reactivity against EBNA-1 and five EBNA-1 domains, and the risk for multiple sclerosis (MS), and to examine if these antibodies and 25(OH)D status interact regarding MS risk in prospectively collected blood samples.
Methods: Antibody reactivity (as specified above) and 25(OH)D levels were measured using ELISAs in n=192 MS cases and n=384 matched controls. The risk for MS was analysed using matched logistic regression.
Results: The risk for MS increased across tertiles of antibody reactivity against EBNA-1, domain EBNA-1402–502, and domain EBNA-1385–420; p trend <0.001. The risk increase was most pronounced for EBNA-1385–420. In young individuals (below median age at sampling, <26.4 years) these associations were stronger, and 25(OH)D levels correlated inversely to antibody reactivity against EBNA-1 and the EBNA-1 domains.
Conclusions: We confirm that increased antibody reactivity against EBNA-1 is a risk factor for MS. Our findings in young individuals suggest that 25(OH)D status might influence the immune response towards Epstein-Barr virus, and thereby modulate MS risk.
Place, publisher, year, edition, pages
Sage Publications, 2013. Vol. 19, no 12, 1587-1591 p.
Multiple sclerosis, Case control study, Risk factors in epidemiology, Epstein-Barr virus (EBV), Epstein-Barr Nuclear Antigen-1 (EBNA-1), Vitamin D (25[OH]D)
Research subject Epidemiology
IdentifiersURN: urn:nbn:se:umu:diva-63746DOI: 10.1177/1352458513483888ISI: 000325696100008OAI: oai:DiVA.org:umu-63746DiVA: diva2:582959