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Ligand binding by PDZ domains
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. ETH. (Chi Celestine)
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2012 (English)In: Biofactors, ISSN 0951-6433, E-ISSN 1872-8081, Vol. 38, no 5, 338-348 p.Article, review/survey (Refereed) Published
Abstract [en]

The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common proteinprotein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well as pathological conditions have been reviewed recently. In this review, we focus on the molecular details of how PDZ domains bind their protein ligands and their potential as drug targets in this context.

Place, publisher, year, edition, pages
2012. Vol. 38, no 5, 338-348 p.
Keyword [en]
PDZ domain, ligand binding
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-187852DOI: 10.1002/biof.1031ISI: 000310070100004OAI: oai:DiVA.org:uu-187852DiVA: diva2:575739
Available from: 2012-12-11 Created: 2012-12-11 Last updated: 2017-10-16Bibliographically approved

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