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A High Ductal Flow Velocity is Associated with Successful Pharmacological Closure of Patent Ductus Arteriosus in Infants 22-27 Weeks Gestational Age
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Perinatal, neonatal och barnkardiologisk forsning/Hellström-Westas)ORCID iD: 0000-0001-8382-8687
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Perinatal, neonatal och barnkardiologisk forsning/Hellström-Westas)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Perinatal, neonatal och barnkardiologisk forsning/Hellström-Westas)
2012 (English)In: Critical Care Research and Practice, ISSN 2090-1305, E-ISSN 2090-1313, 715265- p.Article in journal (Refereed) Published
Abstract [en]

Objective:

To identify factors affecting closure of patent ductus arteriosus (PDA) in newborn infants born at 22-27 weeks gestational age (GA) during pharmacological treatment with cyclooxygenase inhibitors.

Method:

Infants born at 22-27 weeks of GA between January 2006 and December 2009 who had been treated pharmacologically for PDA were identified retrospectively. Medical records were assessed for clinical, ventilatory and outcome parameters. Echocardiographic examinations during treatment were reviewed.

Results:

Fifty-six infants were included in the study. Overall success rate of ductal closure with pharmacological treatment was 52%. Infants whose PDA was successfully closed had a higher GA (25+4 weeks vs. 24+3 weeks; P=0.047), and a higher pre-treatment left to right maximal ductal flow velocity (1.6 m/s vs. 1.1 m/s; P=0.023). Correcting for GA, preeclampsia, antenatal steroids, and age at treatment start, a higher maximal ductal flow velocity was still associated with successful ductal closure (OR 3.04, p=0.049).

Conclusion:

Maximal ductal flow velocity was independently associated with success of PDA treatment.

Place, publisher, year, edition, pages
2012. 715265- p.
Keyword [en]
patent ductus arteriosus, preterm, cyclooxygenase inhibitors, echocardiography
National Category
Medical and Health Sciences Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-187783DOI: 10.1155/2012/715265OAI: oai:DiVA.org:uu-187783DiVA: diva2:575603
Funder
Swedish Heart Lung Foundation, 20100033
Available from: 2012-12-10 Created: 2012-12-10 Last updated: 2017-12-07Bibliographically approved

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