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Influence of poly(N-isopropylacrylamide)-CNT-polyaniline three-dimensional electrospun microfabric scaffolds on cell growth and viability
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
National Institute for Materials Science, Japan.
National Institute for Materials Science, Japan.
National Institute for Materials Science, Japan.
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2013 (English)In: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 99, no 5, 334-341 p.Article in journal (Refereed) Published
Abstract [en]

This study investigates the effect on: 1) the bulk surface; and 2) the three-dimensional non-woven microfabric scaffolds of poly(N-isopropylacylamide)-CNT-polyaniline on growth and viability of  mice fibroblast cells L929. The poly(N-isopropylacylamide)-CNT-polyaniline was prepared using coupling chemistry and electrospinning was then used for the fabrication of responsive, nonwoven microfabric scaffolds. The electrospun microfabrics were assembled in regular three-dimensional scaffolds with OD: 400-500 mm; L: 6-20 cm. Mice fibroblast cells L929 were seeded on the both poly(N-isopropylacylamide)-CNT-polyaniline bulk surface as well as non-woven microfabric scaffolds. Excellent cell proliferation and viability was observed on poly(N-isopropylacylamide)-CNT-polyaniline non-woven microfabric matrices in compare to poly(N-isopropylacylamide)-CNT-polyaniline bulk and commercially available Matrigel™ even with a range of cell lines up to 168 h. Temperature dependent cells detachment behaviour was observed on the poly(N-isopropylacylamide)-CNT-polyaniline scaffolds by varying incubation at below lower critical solution temperature (LCST) of poly(N-isopropylacylamide). The results suggest that poly(N-isopropylacylamide)-CNT-polyaniline non-woven microfabrics could be used as a smart matrices for applications in tissue engineering.

Place, publisher, year, edition, pages
John Wiley & Sons, 2013. Vol. 99, no 5, 334-341 p.
Keyword [en]
smart tissue engineering scaffolds, conducting polymers, carbon nanotubes, responsive-polymers, biocompatible conducting matrices.
National Category
Medical Materials
URN: urn:nbn:se:liu:diva-85583DOI: 10.1002/bip.22170ISI: 000315300100006OAI: diva2:571857
European Commission FP7 (PIIF-GA-2009-254955), JSPS, JST-CREST and MEXT
EU, FP7, Seventh Framework Programme, PIIF-GA-2009- 254955
Available from: 2012-11-28 Created: 2012-11-25 Last updated: 2013-10-04Bibliographically approved

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