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Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
Stockholm Spine Center.
2013 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 24, no 1, p. 1-10Article, review/survey (Refereed) Published
Abstract [en]

Currently available treatments for the degenerated intervertebral disc present disadvantages, such as surgical invasiveness and inadequate load distribution results. Load-bearing, injectable materials may be interesting for future therapies, but have not been studied in depth.

In this study, the existing literature was screened for studies on injectable materials for the intervertebral disc and a rationale for load-bearing, injectable materials was formulated. Requirements for such a material were discussed, partly based on the experience of materials used for similar applications.

Important properties were discussed and found to include biocompatibility, bioactivity, porosity, handling, injectability, working time, setting time, radiopacity, containment and mechanical properties, where several of these properties are linked to one another.

In conclusion, there is a need for consensus on the properties of new materials developed for use in minimally invasive procedures in the spine. A substantial amount of attention may need to be given to non-toxic setting reactions.

Place, publisher, year, edition, pages
2013. Vol. 24, no 1, p. 1-10
National Category
Other Materials Engineering Biomaterials Science
Research subject
Engineering Science with specialization in Materials Science
Identifiers
URN: urn:nbn:se:uu:diva-184804DOI: 10.1007/s10856-012-4776-2ISI: 000313368900001OAI: oai:DiVA.org:uu-184804DiVA: diva2:567927
Available from: 2012-11-16 Created: 2012-11-14 Last updated: 2017-12-07Bibliographically approved

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