Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A Sexual Ornament in Chickens Is Affected by Pleiotropic Alleles at HAO1 and BMP2, Selected during Domestication
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity.
Show others and affiliations
2012 (English)In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 8, no 8, e1002914- p.Article in journal (Refereed) Published
Abstract [en]

Domestication is one of the strongest forms of short-term, directional selection. Although selection is typically only exerted on one or a few target traits, domestication can lead to numerous changes in many seemingly unrelated phenotypes. It is unknown whether such correlated responses are due to pleiotropy or linkage between separate genetic architectures. Using three separate intercrosses between wild and domestic chickens, a locus affecting comb mass (a sexual ornament in the chicken) and several fitness traits (primarily medullary bone allocation and fecundity) was identified. This locus contains two tightly-linked genes, BMP2 and HAO1, which together produce the range of pleiotropic effects seen. This study demonstrates the importance of pleiotropy (or extremely close linkage) in domestication. The nature of this pleiotropy also provides insights into how this sexual ornament could be maintained in wild populations.

Place, publisher, year, edition, pages
2012. Vol. 8, no 8, e1002914- p.
Keyword [en]
GENE-EXPRESSION; COMPLEX TRAITS; DROSOPHILA-MELANOGASTER; INCIPIENT SPECIATION; RED JUNGLEFOWL; QTL; BONE; GENOMICS; CHARACTER; SPERM
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-183912DOI: 10.1371/journal.pgen.1002914ISI: 000308529300066OAI: oai:DiVA.org:uu-183912DiVA: diva2:565366
Available from: 2012-11-07 Created: 2012-11-05 Last updated: 2017-12-07Bibliographically approved

Open Access in DiVA

fulltext(434 kB)321 downloads
File information
File name FULLTEXT01.pdfFile size 434 kBChecksum SHA-512
e0558f1a624bbc0c0ca8228b6c875f092728917b5d2048bf4029589e218c9b2f2e60bee18c21503fce13d2d5043e11dc42c4930ea392c66a46e95e2cb5ec6767
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Rubin, Carl-JohanSahlqvist, Anna-StinaJonsson, Kenneth B.Kerje, SusanneEkwall, OlovKämpe, OlleAndersson, Leif
By organisation
Department of Medical Biochemistry and MicrobiologyAutoimmunityOrthopaedics
In the same journal
PLOS Genetics
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 321 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 894 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf