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Quantification of alpha-synuclein in cerebrospinal fluid
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2012 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

To date there is no accepted clinical diagnostic test for Parkinson's disease (PD) based on biochemical analyses of blood or cerebrospinal uid. Currently, diagnosis, measurement of disease progression and response to therapeutic intervention are based on clinical observation, but the rst neuronal dysfunction precede the earliest recognition of symptom by at least 5 - 10 years. A potential diagnostic biomarker is oligomeric alpha-synuclein which in recent papers have reported a signicant quantitative dierence between PD and controls. In this master thesis, a method for measuring oligomeric levels of alpha-synuclein is presented together with a monomeric measuring commercial kit used to measure alpha-synuclein in a preclinical model of PD. A signicant dierence of monomeric levels could be detected between two weeks and four weeks post injection of a vector containing the gene for human alpha-synuclein, no signicant dierence between four and eight weeks was found.

Place, publisher, year, edition, pages
2012. , 40 p.
Keyword [en]
alpha-synuclein parkinson cerebrospinal fluid biomarker
National Category
Pharmaceutical Biotechnology
Identifiers
URN: urn:nbn:se:liu:diva-84598ISRN: LiTH-IFM-A-EX--12/2591--SEOAI: oai:DiVA.org:liu-84598DiVA: diva2:560511
External cooperation
AstraZeneca
Subject / course
Physics
Uppsok
Medicine
Supervisors
Examiners
Available from: 2012-11-20 Created: 2012-10-15 Last updated: 2012-11-20Bibliographically approved

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Quantification of alpha-synuclein in cererospinal fluid(3440 kB)333 downloads
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Pharmaceutical Biotechnology

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CiteExportLink to record
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  • apa
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