Motility or spontaneous motion of eukaryotic cells, such as white blood cells, has been
extensively studied in the recent literature. A mechanism has been established based
on polymerization of actin filaments that pushes the cell wall forwards. However, many
features of this phenomenon remain incompletely understood and more insights from
modeling is desirable. We study the problem of understanding the origin and magnitude
of the velocity achieved by the moving cells, and compare it with existing experimental
results. We have developed and simulated a simplified model based on the relevant
features of eukaryotic protrusion, formulating main elements required to describe the
cellular motility. The main simplification is the isolation of a few actin filaments, whereas
other similar models have previously been built on more complicated cases of polymer
ensembles. The strength of the simplified model is that it clarifies the actual e
elements of cellular protrusion. A computer program simulates the growth of an actin
polymer behind a cellular membrane and delivers the protrusion speed of the eukaryotic.
We also construct a real time 3D graphical representation of the movement process.
The results obtained are in reasonable agreement with experimental results for the cell
velocity. The agreement is actually improved compared to previous studies of more
complicated models, indicating that our simplified model indeed seems to work very
well. Moreover, the detailed graphical representation highlights the process in greater
detail than has previously been achieved.
2011. , 30 p.