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The theory of metal electronucleation applied to the study of fundamental properties of liposomes
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
2013 (English)In: Journal of Solid State Electrochemistry, ISSN 1432-8488, E-ISSN 1433-0768, Vol. 17, no 2 (SI), 299-305 p.Article, review/survey (Refereed) Published
Abstract [en]

This short review describes how the theory of electrochemical metal nucleation considering non-stationary effects due to the activation of latent nucleation sites has been successfully translated and applied to describe phenomena observed on lipid membranes. This rather unexpected connection is merely formal, but has resulted in a completely new approach in liposome research. It has been proposed that hydrophobic active sites spontaneously and constantly appear and disappear on lipid membranes. These sites control the affinity of liposomes for hydrophobic surfaces and determine the permeability of the lipid membrane to small hydrophilic molecules. Thus, the kinetic models for liposome adhesion on hydrophobic substrates and for the spontaneous leakage of liposomal content are identical to that of non-stationary nucleation mentioned above. Therefore, the broad scope of the available work on metal nucleation has facilitated the interpretation of the data obtained in liposome research. Future applications of the nucleation model in the realm of liposomes are also discussed.

Place, publisher, year, edition, pages
Springer, 2013. Vol. 17, no 2 (SI), 299-305 p.
Keyword [en]
Liposomes, nucleation kinetics, hydrophobic active sites, mercury electrode
National Category
Physical Chemistry Natural Sciences
URN: urn:nbn:se:uu:diva-181528DOI: 10.1007/s10008-012-1874-5ISI: 000313800200003OAI: diva2:556539
Available from: 2012-09-25 Created: 2012-09-25 Last updated: 2013-02-27Bibliographically approved

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Agmo Hernández, Víctor
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