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An investigation of protective formulations containing enzyme inhibitors: Model experiments of trypsin
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
2012 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

This master thesis considers an investigation of protective formulations (ointment, cream) containing enzyme inhibitors. Model experiments have been made on the enzyme trypsin. It is well accepted that feces and urine are an important causing factor for skin irritation (dermatitis) while using diaper. A protective formulation is a physical barrier that separates the harmful substances from the skin. It can also be an active barrier containing active substances, which can be active both towards the skin, and the substances from feces and urine. By preventing contact from these substances the skin will not be harmed, at least for a period of time. A number of different inhibitors were tested towards trypsin and they all showed good inhibition, two of the inhibitors were selected to be immobilized with the help of NHS-­activated Sepharose. Immobilization of these two inhibitors leads to a lesser extent of the risk of developing allergy and also that the possible toxic effect can be minimized. 

Place, publisher, year, edition, pages
2012. , 38 p.
UPTEC K, ISSN 1650-8297 ; 12018
Keyword [en]
Trypsin, immobilized, dermatitis, NHS-agarose, inhibitor, protective formulations, enzyme inhibitor, active barrier, NHS-activated Sepharose
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-181173OAI: diva2:553292
External cooperation
Svenska Cellulosa Aktiebolaget
Educational program
Master Programme in Chemical Engineering
Available from: 2012-10-24 Created: 2012-09-18 Last updated: 2012-10-24Bibliographically approved

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