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Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study
Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet.
Department of Biological Sciences, National University of Singapore.
Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. Kristianstad University, Forskningsmiljön Biomedicin.ORCID iD: 0000-0002-9355-3901
Department of Otolaryngology, National University of Singapore.
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2012 (English)In: BMC Medical Genetics, ISSN 1471-2350, Vol. 13, no 1, 66- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes.

METHODS:A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls.

RESULTS:The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region. Subsequent analysis of 24 SNPs from this region identified 7 and 5 significant SNPs from the Swedish and Chinese populations, respectively. The corresponding riskassociated haplotypes are significant after Bonferroni correction and are the most common haplotypes in both populations. The associations are primarily detected in females in the Swedish population, whereas it is seen in males in the Chinese population. Further independent support for the involvement of this region in allergic rhinitis was obtained from quantitative skin prick test data generated in both populations.

CONCLUSIONS:Haplotypes in the TLR7-TLR8 gene region were associated with allergic rhinitis in one Swedish and one Chinese population. Since this region has earlier been associated with asthma and allergic rhinitis in a Danish linkage study this speaks strongly in favour of this region being truly involved in the development of this disease.

Place, publisher, year, edition, pages
2012. Vol. 13, no 1, 66- p.
Keyword [en]
Allergic rhinitis, Toll-like receptor, Polymorphism, Genetics, Haplotype, Case–control
National Category
Medical Genetics
URN: urn:nbn:se:hkr:diva-9618DOI: 10.1186/1471-2350-13-66ISI: 000309423900001OAI: diva2:546287
Available from: 2012-08-23 Created: 2012-08-23 Last updated: 2014-06-10Bibliographically approved

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