Immunogenicity of HIV Virus-Like Particles in Rhesus Macaques by Intranasal Administration
2012 (English)In: Clinical and Laboratory Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 19, no 6, 970-973 p.Article in journal (Refereed) Published
Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.
Place, publisher, year, edition, pages
American Society for Microbiology , 2012. Vol. 19, no 6, 970-973 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-80202DOI: 10.1128/CVI.00068-12ISI: 000307110500023OAI: oai:DiVA.org:liu-80202DiVA: diva2:546209
funding agencies|Simian Vaccine Evaluation Unit (SVEU) of the Division of AIDS||European Community|201433|2012-08-222012-08-222016-09-07Bibliographically approved