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Immunogenicity of HIV Virus-Like Particles in Rhesus Macaques by Intranasal Administration
Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy.
Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy.
Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy.
Bioqual Inc., Rockville, Maryland, USA.
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2012 (English)In: Clinical and Laboratory Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 19, no 6, 970-973 p.Article in journal (Refereed) Published
Abstract [en]

Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.

Place, publisher, year, edition, pages
American Society for Microbiology , 2012. Vol. 19, no 6, 970-973 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-80202DOI: 10.1128/CVI.00068-12ISI: 000307110500023OAI: diva2:546209

funding agencies|Simian Vaccine Evaluation Unit (SVEU) of the Division of AIDS||European Community|201433|

Available from: 2012-08-22 Created: 2012-08-22 Last updated: 2016-09-07Bibliographically approved

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Hinkula, Jorma
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