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Inheritance beyond plain heritability: variance-controlling genes in Arabidopsis thaliana
Dalarna University, School of Technology and Business Studies, Statistics.ORCID iD: 0000-0003-4390-1979
Dalarna University, School of Technology and Business Studies, Statistics.ORCID iD: 0000-0002-1057-5401
2012 (English)In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 8, no 8, e1002839Article in journal (Refereed) Published
Abstract [en]

The phenotypic effect of a gene is normally described by the mean-difference between alternative genotypes. A gene may, however, also influence the phenotype by causing a difference in variance between genotypes. Here, we reanalyze a publicly available Arabidopsis thaliana dataset [1] and show that genetic variance heterogeneity appears to be as common as normal additive effects on a genomewide scale. The study also develops theory to estimate the contributions of variance differences between genotypes to the phenotypic variance, and this is used to show that individual loci can explain more than 20% of the phenotypic variance. Two well-studied systems, cellular control of molybdenum level by the ion-transporter MOT1 and flowering-time regulation by the FRI-FLC expression network, and a novel association for Leaf serration are used to illustrate the contribution of major individual loci, expression pathways, and gene-by-environment interactions to the genetic variance heterogeneity.

Place, publisher, year, edition, pages
2012. Vol. 8, no 8, e1002839
National Category
Genetics
Research subject
Complex Systems – Microdata Analysis, Statistisk modellering är grunden till en ökad förståelse inom genetik!; Complex Systems – Microdata Analysis, General Microdata Analysis - methods
Identifiers
URN: urn:nbn:se:du-10538DOI: 10.1371/journal.pgen.1002839ISI: 000308529300006PubMedID: 22876191OAI: oai:DiVA.org:du-10538DiVA: diva2:543921
Funder
Swedish Research Council Formas
Available from: 2012-08-10 Created: 2012-08-10 Last updated: 2017-12-07Bibliographically approved

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