Change search
ReferencesLink to record
Permanent link

Direct link
Impaired Adaptive Response to Mechanical Overloading in Dystrophic Skeletal Muscle
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
Show others and affiliations
2012 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 7, no 4, e35346- p.Article in journal (Refereed) Published
Abstract [en]

Dystrophin contributes to force transmission and has a protein-scaffolding role for a variety of signaling complexes in skeletal muscle. In the present study, we tested the hypothesis that the muscle adaptive response following mechanical overloading (ML) would be decreased in MDX dystrophic muscle lacking dystrophin. We found that the gains in muscle maximal force production and fatigue resistance in response to ML were both reduced in MDX mice as compared to healthy mice. MDX muscle also exhibited decreased cellular and molecular muscle remodeling (hypertrophy and promotion of slower/oxidative fiber type) in response to ML, and altered intracellular signalings involved in muscle growth and maintenance (mTOR, myostatin, follistatin, AMPK alpha 1, REDD1, atrogin-1, Bnip3). Moreover, dystrophin rescue via exon skipping restored the adaptive response to ML. Therefore our results demonstrate that the adaptive response in response to ML is impaired in dystrophic MDX muscle, most likely because of the dystrophin crucial role.

Place, publisher, year, edition, pages
2012. Vol. 7, no 4, e35346- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-177635DOI: 10.1371/journal.pone.0035346ISI: 000305338600072OAI: diva2:541386
Available from: 2012-07-17 Created: 2012-07-17 Last updated: 2012-07-17Bibliographically approved

Open Access in DiVA

fulltext(2146 kB)80 downloads
File information
File name FULLTEXT01.pdfFile size 2146 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Ochala, Julien
By organisation
Clinical Neurophysiology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 80 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 209 hits
ReferencesLink to record
Permanent link

Direct link