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Synthesis of multicyclic 2-pyridones from a formyl and chlorometylene substituted precursor using a strategy of directed diversity-oriented synthesis
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2012 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

Multi ring-fused 2-pyridones have shown interesting activity in a variety of biological systems. It would be of great interest to explore the biological application of even more multi heterocyclic ring fused 2-pyridones. ‘Diversity oriented synthesis’ is an excellent concept emerged in recent years to access compounds with structurally and stereochemically diverse skeletons. This served as an efficient avenue for synthesizing various ring fused 2-pyridones using formyl, chloromethylene substituted 2-pyridone (

6) as a starting compound. By treating the starting material (6) with various nucleopliles, different sized heterocyclic ring fused 2-pyridones has been synthesized. Additionally, an improved methodology for the synthesis of naphthyridones was presented.

Place, publisher, year, edition, pages
2012. , 23 p.
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-56763OAI: oai:DiVA.org:umu-56763DiVA: diva2:537415
Educational program
Master’s program in Chemistry
Uppsok
Physics, Chemistry, Mathematics
Supervisors
Examiners
Available from: 2012-06-26 Created: 2012-06-26 Last updated: 2012-06-26Bibliographically approved

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