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The platelet-derived growth factor (PDGF) family of tyrosine kinase receptors: a Kit to fix the beta cell?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2012 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 55, no 8, 2092-2095 p.Article, review/survey (Refereed) Published
Abstract [en]

Overexpression of c-Kit has recently been shown to ameliorate beta cell function by increasing the beta cell mass and insulin secretion, thus counteracting the deleterious effects of a high fat diet on glucose homeostasis. The c-Kit dependent effects are due to enhanced Akt activity that phosphorylates and inhibits the Gsk-3b kinase, thereby increasing the expression of numerous genes that promote insulin production and cell proliferation. Regulating the c–Kit/Akt/Gsk-3b pathway may provide novel means for improving beta cell function in type 2 diabetes.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2012. Vol. 55, no 8, 2092-2095 p.
Keyword [en]
diabetes, tyrosine kinase receptor, beta cells
National Category
Medical and Health Sciences
Research subject
Biology with specialization in Molecular Cell Biology
URN: urn:nbn:se:uu:diva-175252DOI: 10.1007/s00125-012-2611-4OAI: diva2:530685
Swedish Research Council, K2011-54X-10822-18-6
Available from: 2012-06-08 Created: 2012-06-04 Last updated: 2012-12-06Bibliographically approved

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