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Multipel Skleros En kartläggning av infektionskomplikationer i samband med hematopoetisk stamcellstransplantation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
2012 (Swedish)Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]


Multiple sclerosis (MS) is the leading cause of adult disability inSweden. Hematopoietic stem cell transplantation (HSCT) can be used as a treatment option for patients with MS where the disease has an aggressive course. The treatment is preceded by high-dose chemotherapy which lowers the patient's immune system. It is therefore of interest to study infectious complications associated with HSCT in this patient.

Aim: The purpose of this study was to identify infection problems in this population associated with HSCT, and to study differences in infectious complications between this group and patients diagnosed with lymphoma who have undergone the same treatment.Method: The study was a retrospective descriptive study with quantitative data. A medical record review was conducted. The analysis of the results was used Statistical Package for the Social Sciences (SPSS) version 19th Independent t-tests were used as the statistical analysis to measure the difference between two groups at the same time.Result: The results showed that there were differences in fever period. Patients with MS had a significantly longer fever period than patients with lymphoma. It did not affect the number of days in hospital. Patients with MS had a shorter period of neutropenia but significantly more positive blood cultures.Conclusion: Patients with MS who are treated with HSCT are at high risk of infection. The risk of infectious complications is greater than in patients treated for lymphoma. We need to consider this finding to the clinical management of patients with MS associated with HSCT.


“Keywords: multiple sclerosis, hematopoietic stem cell transplantation, infection, complicationn”


Abstract [sv]


Multipel skleros (MS) är den vanligaste orsaken till rörelsehinder hos vuxna i Sverige. Hematopoetisk stamcellstransplantation (HSCT) kan användas som en behandlingsform för patienter med MS där sjukdomsförloppet är aggressivt. Behandlingen föregås av höga doser cytostatika vilket sänker patientens immunförsvar. Det är därför av intresse att studera infektionskomplikationer i samband med HSCT hos denna patientgrupp.

Syfte: Syftet med studien var att kartlägga infektionsproblematik hos patienter med MS i samband med HSCT samt att studera skillnader i infektionskomplikationer mellan denna grupp och patienter med diagnosen lymfom som genomgått samma behandlingsform.

Metod: Studien var en retrospektiv deskriptiv studie med kvantitativ ansats. En journalgranskning genomfördes. I analysen av resultatet användes Statistical Package for the Social Sciences (SPSS) version 19.  Oberoende t-test har använts som statistisk analys för att mäta skillnaden mellan två grupper vid samma tidpunkt.

Resultat: Resultatet visade att det fanns skillnader i feberdurationens längd. Patienter med MS hade en signifikant längre feberperiod än patienterna med lymfom. Det påverkade dock inte antalet vårddagar. Patienterna med MS hade en kortare neutropeniperiod men signifikant fler positiva blododlingar.

Slutsats: Patienter med MS som behandlas med HSCT löper stor risk för infektioner. Risken för infektionskomplikationer är inte mindre än hos patienter som behandlas för lymfom, utan större. Man behöver ta hänsyn till detta fynd vid den kliniska handläggningen av patienter med MS i samband med HSCT.


”Nyckelord: multipel skleros, hematopoetisk stamcellstransplantation, infektion, komplikation”








Place, publisher, year, edition, pages
2012. , 27 p.
Keyword [sv]
multipel skleros, hematopoetisk stamcellstransplantation, infektion, komplikation
National Category
URN: urn:nbn:se:uu:diva-175230OAI: diva2:530629
Subject / course
Caring Sciences
Educational program
Freestanding course
Available from: 2012-06-05 Created: 2012-06-04 Last updated: 2012-06-05Bibliographically approved

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MS infektionskomlikationer vid HSCT(252 kB)287 downloads
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