Change search
ReferencesLink to record
Permanent link

Direct link
Molecular evolution of voltage-gated calcium channels of L and N types and their genomic regions
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2012 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The expansion of the voltage-gated calcium channel alpha 1 subunit families (CACNA1) of L and N types was investigated by combining phylogenetic analyses (neighbour-joining and maximum likelihood) with chromosomal data. Neighbouring gene families were analysed to see if the chromosomal regions duplicated through whole genome doublings in vertebrates. Results show that both types of CACNA1 expanded in two ancient whole genome duplications as parts of larger genomic regions. Many gene families in these regions obtained copies in an additional teleost-specific genome duplication. This diversification of CACNA1 genes probably contributed to evolutionary innovations in nervous system function.

Place, publisher, year, edition, pages
2012. , 57 p.
Keyword [en]
Evolution, vertebrate, voltage-gated calcium channel, whole genome duplication
National Category
URN: urn:nbn:se:uu:diva-173723OAI: diva2:524904
Educational program
Molecular Biotechnology Engineering Programme
Available from: 2012-05-04 Created: 2012-05-04 Last updated: 2012-05-04Bibliographically approved

Open Access in DiVA

fulltext(1069 kB)84 downloads
File information
File name FULLTEXT01.pdfFile size 1069 kBChecksum SHA-512
Type fulltextMimetype application/pdf

By organisation
Biology Education Centre

Search outside of DiVA

GoogleGoogle Scholar
Total: 84 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 271 hits
ReferencesLink to record
Permanent link

Direct link