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Chemical stability of grain boundariesin β-tricalcium phosphate ceramics: β-TCP as bone substitute material
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
2012 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

β – Tricalcium phosphate (β-TCP, Ca3(PO4)2) is a commonly used bone substitute material due to its biocompatibility and resorption. This study focused on the production of almost fully dense β-TCP ceramics with varying degrees of impurities (Ca/PO4 ratio, addition of 5% Mg). Three methods were used to produce the β-TCP ceramics, uniaxial pressing, slip-casting and isostatic pressing. In this study the isostatic pressing and sintering at 1150ºC for 20h and 15min, resulted in the densest β-TCP ceramics (97.7-99.2%). No significant differences of grain size and density could be detected between the samples produced with various compositions. These isostatically pressed samples sintered at 1150ºC were then dissolved in 0.08M aceticacid solution to simulate the in vivo resorption. It was found that the samples containing extra Mg dissolved slower. Attempts to determine the chemical composition of the grain boundaries were made without success. However, SEM observations of partly dissolved β-TCP ceramics revealed that the grain boundaries dissolved faster than the grains. The study was performed at the RMS foundation in Switzerland.

Place, publisher, year, edition, pages
2012. , 41 p.
UPTEC K, ISSN 1650-8297 ; 12002
Keyword [en]
grain boundaries, β-tricalcium phosphate, ceramics
National Category
Other Chemical Engineering
URN: urn:nbn:se:uu:diva-173285OAI: diva2:517211
External cooperation
RMS Foundation
Subject / course
Educational program
Master Programme in Chemical Engineering
Available from: 2012-04-23 Created: 2012-04-22 Last updated: 2012-04-23Bibliographically approved

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