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Comparison and Optimization of Insonation Strategies for Contrast Enhanced Ultrasound Imaging
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
2012 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Evolution of vulnerable carotid plaques are crucial reason for cerebral ischemic strokes and identifying them in the early stage can become very important in avoiding the risk of stroke. In order to improve the identification and quantification accuracy of infancy plaques better visualization techniques are needed. Improving the visualization and quantification of neovascularization in carotid plaque using contrast enhanced ultrasound imaging still remains a challenging task. In this thesis work, three optimization techniques are proposed, which showed an improvement in the sensitivity of contrast agents when compared to the conventional clinical settings and insonation strategies. They are as follows:1) Insonation at harmonic specific (2nd harmonic) resonance frequency instead of resonance frequency based on maximum energy absorption provides enhanced nonlinear contribution.2) At high frequency ultrasound imaging, shorter pulse length will provide improved harmonic signal content when compared to longer pulse lengths. Applying this concept to multi- pulse sequencing (Pulse Inversion and Cadence contrast pulse sequencing) resulted in increased magnitude of the remaining harmonic signal after pulse summations.3) Peak negative pressure optimization of Pulse Inversion and Cadence contrast pulse sequencing was showed to further enhance the nonlinear content of the backscattered signal from contrast microbubbles without increasing the safety limits, defined by the mechanical index.The results presented in this thesis are based on computational modeling (Bubblesim software) and as a future continuation we plan to verify the simulation results with vitro studies.

Place, publisher, year, edition, pages
2012. , 100 p.
Keyword [en]
Introduction to Medical Ultrasound, Ultrasound Contrast Agents, Ultrasound Contrast for Carotid Plaques, Contrast enhanced ultrasound imaging, Bubble Theory, Nonlinear imaging, Ultrasound imaging, Pulse inversion, Cadence contrast pulse sequence
National Category
Medical Image Processing
URN: urn:nbn:se:liu:diva-76646ISRN: LiTH-IMT/MASTER--12/013--SEOAI: diva2:515651
Subject / course
Masterprogram Biomedical Engineering (BME)
2012-02-08, IMT1, Linköpings universitet, IMT, Campus US, Linköping, 10:00 (English)
Available from: 2012-04-19 Created: 2012-04-13 Last updated: 2012-06-12Bibliographically approved

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